2-(4-methoxyphenyl)-1,3-dioxane-4,6-dione | 160693-23-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 2-(4-methoxyphenyl)-1,3-dioxane-4,6-dione
• CAS: 160693-23-2
• 化学式: C₁₁H₁₀O₅
• 分子量: 222.197
• InChiKey: ATAQMBQQINQEJY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  61.8
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2,4-二氯苯基异氰酸酯 、 2-(4-methoxyphenyl)-1,3-dioxane-4,6-dione 在 三乙胺 作用下， 以89%的产率得到N-(2,4-dichlorophenyl)-4-hydroxy-2-(4-methoxyphenyl)-6-oxo-1,3-dioxine-5-carboxamide
  参考文献：
  名称：

  A new class of inhibitors of secretory phospholipase A2: enolized 1,3-dioxane-4,6-dione-5-carboxamides

  摘要：

  Enolized 1,3-dioxane-4,6-dione-5-carboxamides a were identified as a new class of inhibitors of secretory phospholipase A(2) from human polymorphonuclear leucocytes (h-PMN PLA(2)). Among the more than 30 compounds synthesized, the most potent inhibitors (IC50 0.6-10 mu M) were found in the series of 2,4-disubstituted phenyl analogues of a. Compound 1a was selected for evaluation of its biological profile. This substance potently inhibited secretory PLA(2)s from several sources other than human PMNs, with a clear preference for group II over group I PLA(2), whereas human cytosolic PLA(2) and phospholipase C were not significantly affected. Inhibition of h-PMN PLA(2) was calcium-dependent. In intact mammalian cells stimulated in vitro, the release of arachidonic acid and the generation of prostaglandins and leukotrienes were inhibited at concentrations compatible with inhibition of PLA(2) as an underlying mechanism. In animal models in vivo (carragheenan oedema, adjuvant arthritis, pertussis pleurisy) 1a showed antiinflammatory activity, although the effect was rather weak compared with standard reference compounds.

  DOI：

  10.1016/0223-5234(94)90026-4
• 作为产物：
  描述：

  丙二酸 、 4-甲氧基苯甲醛 在 硫酸 、 乙酸酐 作用下， 反应 48.0h， 以29%的产率得到2-(4-methoxyphenyl)-1,3-dioxane-4,6-dione
  参考文献：
  名称：

  从联芳基和 Meldrum 酸衍生物合成芴及其相关化合物

  摘要：

  开发了一种由含氨基联芳基和麦氏酸衍生物制备芴的新合成方法。该反应在没有催化剂和官能团损失的情况下进行。分别以联芳基醚和邻三联苯为底物得到相应的六元和七元环状产物。

  DOI：

  10.1039/d1cc06212c

文献信息

• Benzazepine derivatives
  申请人：E. R. Squibb & Sons, Inc.

  公开号：US04752645A1

  公开（公告）日：1988-06-21

  Vasodilating activity is exhibited by compounds having the formula ##STR1## and pharmaceutically acceptable salts thereof.

  具有如下式子##STR1##和其药学上可接受的盐，表现出扩张血管的活性。
• A Facile Synthesis of Novel and Stable Phosphorus Ylides Containing 2-Aryl-1,3-Dioxane-4,6-Dione
  作者：Azizollah Habibi、Hedyeh Hosseinzadeh、Seyed Majid Aghvami

  DOI：10.1080/10426507.2011.621001

  日期：2012.3.1

  Abstract The reaction between dialkyl acetylene dicarboxylate and 2-aryl-1,3-dioxane-4,6-dione derivatives in the presence of triphenylphosphine in ethyl acetate led to stable phosphorus ylides in good yields. These stabilized phosphorus ylides exist as a mixture of two geometrical isomers as a result of restricted rotation around the carbon–carbon partial double bond. The 1H NMR variable temperature spectra

  摘要乙炔二羧酸二烷基酯与 2-芳基-1,3-二恶烷-4,6-二酮衍生物在三苯基膦存在下在乙酸乙酯中的反应以良好的收率得到稳定的磷叶立德。由于围绕碳-碳部分双键的旋转受限，这些稳定的磷叶立德以两种几何异构体的混合物形式存在。研究了 3c 的 1H NMR 变温光谱并报告了结果。图形概要
• CARBON FIBER MOLDING MATERIAL, MOLDING MATERIAL, AND CARBON FIBER-STRENGTHENING COMPOSITE MATERIAL
  申请人：Toray Industries, Inc.

  公开号：EP2789648A1

  公开（公告）日：2014-10-15

  Provided is a carbon fiber forming raw material having excellent interfacial adhesion between carbon fibers and a thermosetting resin and capable of giving a molded article having excellent mechanical characteristics. The carbon fiber forming raw material is a carbon fiber forming raw material (Z) as a prepreg including sizing agent-coated carbon fibers and a thermosetting resin or a carbon fiber forming raw material (Y) as a forming material that includes sizing agent-coated carbon fibers and has a woven fabric form or a braid form. The sizing agent includes components (A) and (B). The component (A) is an epoxy compound having two or more epoxy groups or two or more types of functional groups. The component (B) is one or more compounds selected from the group consisting of a tertiary amine compound, a tertiary amine salt, a quaternary ammonium salt, a quaternary phosphonium salt, and a phosphine compound. The component (B) is contained in an amount of 0.1 to 25 parts by mass relative to 100 parts by mass of the component (A).

  本发明提供了一种碳纤维成型原料，该原料在碳纤维和热固性树脂之间具有极佳的界面粘附性，并能使成型品具有极佳的机械特性。该碳纤维成型原料是一种碳纤维成型原料（Z），作为预浸料，包括上浆剂包覆的碳纤维和热固性树脂；或者是一种碳纤维成型原料（Y），作为成型材料，包括上浆剂包覆的碳纤维，并具有编织物或编织物的形态。上浆剂包括组分（A）和（B）。组分（A）是具有两个或两个以上环氧基团或两种或两种以上官能团的环氧化合物。组分（B）是一种或多种化合物，选自由叔胺化合物、叔胺盐、季铵盐、季鏻盐和膦化合物组成的组。相对于 100 重量份的组分（A），组分（B）的含量为 0.1 至 25 重量份。
• POLYMERIZABLE COMPOSITION FOR OPTICAL MATERIAL, AND OPTICAL MATERIAL AND PLASTIC LENS OBTAINED FROM COMPOSITION
  申请人：Mitsui Chemicals, Inc.

  公开号：EP3351564A1

  公开（公告）日：2018-07-25

  A polymerizable composition for an optical material according to the present invention, including: a monomer mixture (A) including a polymerizable monomer having a (meth) acrylic group, a photochromic compound (B) which is at least one selected from compounds represented by Formulae (1) and (2) ; and an ultraviolet absorbing agent (C) which is at least one selected from compounds represented by Formulae (a) to (c) .         PC-L-Chain     (1)         PC-L-Chain-L'-PC'     (2)

  根据本发明，一种用于光学材料的可聚合组合物，包括：单体混合物（A），其中包括具有（甲基）丙烯酸基团的可聚合单体；光致变色化合物（B），该化合物至少选自式（1）和（2）所代表的化合物中的一种；以及紫外线吸收剂（C），该紫外线吸收剂至少选自式（a）至（c）所代表的化合物中的一种。 PC-L-链（1） PC-L-链-L'-PC'（2）
• POLYMERIZABLE COMPOSITION FOR OPTICAL MATERIALS, OPTICAL MATERIAL OBTAINED FROM SAID COMPOSITION, AND PLASTIC LENS
  申请人：Mitsui Chemicals, Inc.

  公开号：EP3351574A1

  公开（公告）日：2018-07-25

  A polymerizable composition for an optical material according to the present invention includes a polyisocyanate compound (A), a polyol compound (B) having a number average molecular weight of 100 or more, a difunctional or higher functional active hydrogen compound (C) (but, excluding the compound (B)), a photochromic compound (D), and an ultraviolet absorber (E).

  根据本发明，用于光学材料的可聚合组合物包括多异氰酸酯化合物（A）、平均分子量大于等于 100 的多元醇化合物（B）、双官能团或更高官能团的活性氢化合物（C）（但不包括化合物（B））、光致变色化合物（D）和紫外线吸收剂（E）。