3-{5-[(4-chlorophenyl)(methyl)amino]picolinoyl}-5-phenylsulfanylbenzoic acid | 1244043-18-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-{5-[(4-chlorophenyl)(methyl)amino]picolinoyl}-5-phenylsulfanylbenzoic acid
• 英文别名: 3-{5-[(4-chlorophenyl)methylamino]pyridine-2-carbonyl}-5-phenylsulfanyl-benzoic acid；3-[5-(4-chloro-N-methylanilino)pyridine-2-carbonyl]-5-phenylsulfanylbenzoic acid
• CAS: 1244043-18-2
• 化学式: C₂₆H₁₉ClN₂O₃S
• 分子量: 474.967
• InChiKey: NCZBEHDNCUYRCV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.4
• 重原子数：
  33
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.04
• 拓扑面积：
  95.8
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• Bis Aromatic Compounds for Use as LTC4 Synthase Inhibitors
  申请人：Nilsson Peter

  公开号：US20110319431A1

  公开（公告）日：2011-12-29

  There is provided compounds of formula I, wherein Y, ring A, D 1 , D 2a , D 2b , D 3 , L 1 , Y 1 , L 3 and Y 3 have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of diseases in which inhibition of leukotriene C 4 synthase is desired and/or required, and particularly in the treatment of a respiratory disorder and/or inflammation.

  提供了式I的化合物，其中Y、环A、D1、D2a、D2b、D3、L1、Y1、L3和Y3的含义在说明中给出，并且其药学上可接受的盐，这些化合物在治疗需要和/或需要抑制白三烯C4合酶的疾病中是有用的，特别是在治疗呼吸道疾病和/或炎症方面。
• [EN] BIS AROMATIC COMPOUNDS FOR USE AS LCT4 SYNTHASE INHIBITORS<br/>[FR] COMPOSÉS BIS-AROMATIQUES DESTINÉS À ÊTRE UTILISÉS EN TANT QU'INHIBITEURS DE LTC4 SYNTHASE
  申请人：BIOLIPOX AB

  公开号：WO2010103279A1

  公开（公告）日：2010-09-16

  There is provided compounds of formula I, wherein Y, ring A, Da, Db, D2, D3, L1, Y1, L2, Y2, L3 and Y3 have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of diseases in which inhibition of leukotriene C4 synthase is desired and/or required, and particularly in the treatment of a respiratory disorder and/or inflammation.