2-hydroxy-1-nonyl-4-oxo-N-(pyrazin-2-yl)-1,4-dihydroquinoline-3-carboxamide | 384376-45-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2-hydroxy-1-nonyl-4-oxo-N-(pyrazin-2-yl)-1,4-dihydroquinoline-3-carboxamide
• 英文别名: 4-hydroxy-1-nonyl-2-oxo-N-pyrazin-2-ylquinoline-3-carboxamide
• CAS: 384376-45-8
• 化学式: C₂₃H₂₈N₄O₃
• 分子量: 408.5
• InChiKey: GXRCZNUMISGUBY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  30
• 可旋转键数：
  10
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  95.4
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-hydroxy-1-nonyl-4-oxo-N-(pyrazin-2-yl)-1,4-dihydroquinoline-3-carboxamide 在 溴 、 溶剂黄146 作用下， 生成
  参考文献：
  名称：

  4-Hydroxy-2-quinolones. 168*. Synthesis, chemical and antitubercular properties of 1-R-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid pyrazin-2-ylamides

  摘要：

  1-R-4-Hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid pyrazin-2-ylamides have been synthesized as potential antitubercular agents. In contrast to pyrimidin-2-ylamides the compounds prepared are brominated by molecular bromine in glacial acetic acid at position 6 of the quinolone ring rather than in the amide part of the molecule. The 1-N-allyl derivative behaves similarly but undergoes halocyclization to give 2-bromomethyl-5-oxo-1,2-dihydro-5H-oxazolo[3,2-a] quinoline-4-carboxylic acid pyrazin-2-ylamide. A comparative analysis of the antimycobacterial properties of the synthesized compounds and their isomeric pyrimidin-2-ylamides has been carried out.

  DOI：

  10.1007/s10593-009-0384-6