Benzyl 2,2-diphenylhydrazine-1-carboxylate | 37637-38-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Benzyl 2,2-diphenylhydrazine-1-carboxylate
• 英文别名: benzyl N-(N-phenylanilino)carbamate
• CAS: 37637-38-0
• 化学式: C₂₀H₁₈N₂O₂
• 分子量: 318.375
• InChiKey: VJBKDXVFRGAVTA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  24
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  41.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  二氧化碳 、 1,1-二苯肼盐酸盐 、 溴甲苯 在 四丁基碘化铵 、 caesium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 28.0h， 以58%的产率得到Benzyl 2,2-diphenylhydrazine-1-carboxylate
  参考文献：
  名称：

  Mild and efficient synthesis of carbazates and dithiocarbazates via a three-component coupling using Cs 2 CO 3 and TBAI

  摘要：

  Efficient methods for the synthesis of carbazates and dithiocarbazates have been developed. In the presence of cesium carbonate (CS2CO3) and tetrabutylammonium iodide (TBAI) a hydrazine, CO2 or CS2, and an alkyl halide underwent a three component coupling at room temperature. Various unprotected hydrazines and alkyl halides were examined and the results demonstrated this methodology was highly chemoselective. Applications toward the synthesis of azadepsipeptides and other pseudopeptides are described. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2003.10.144

文献信息

• Mild and efficient synthesis of carbazates and dithiocarbazates via a three-component coupling using Cs 2 CO 3 and TBAI
  作者：Daniel L. Fox、John T. Ruxer、John M. Oliver、Kasey L. Alford、Ralph Nicholas Salvatore

  DOI：10.1016/j.tetlet.2003.10.144

  日期：2004.1

  Efficient methods for the synthesis of carbazates and dithiocarbazates have been developed. In the presence of cesium carbonate (CS2CO3) and tetrabutylammonium iodide (TBAI) a hydrazine, CO2 or CS2, and an alkyl halide underwent a three component coupling at room temperature. Various unprotected hydrazines and alkyl halides were examined and the results demonstrated this methodology was highly chemoselective. Applications toward the synthesis of azadepsipeptides and other pseudopeptides are described. (C) 2003 Elsevier Ltd. All rights reserved.