2-[N-(4-Acetylbenzoyl)amino]-4-[(2-diisopropylaminoethyl)aminocarbonyl]-1,3-thiazole.hydrochloride | 206881-87-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-[N-(4-Acetylbenzoyl)amino]-4-[(2-diisopropylaminoethyl)aminocarbonyl]-1,3-thiazole.hydrochloride
• 英文别名: 2-[(4-acetylbenzoyl)amino]-N-[2-[di(propan-2-yl)amino]ethyl]-1,3-thiazole-4-carboxamide;hydrochloride
• CAS: 206881-87-0
• 化学式: C₂₁H₂₈N₄O₃S*ClH
• 分子量: 453.005
• InChiKey: QDKVTBVKURBPAG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.87
• 重原子数：
  30
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  120
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• SUBSTITUTED BENZOYLAMINOTHIAZOLE DERIVATIVES AND DRUGS CONTAINING THE SAME
  申请人：ZERIA PHARMACEUTICAL CO., LTD.

  公开号：EP0934938A1

  公开（公告）日：1999-08-11

  The present invention relates to a substituted benzoylaminothiazole derivative represented by the following formula (I): wherein X represents an imino group which may be substituted by a lower alkyl group, or an oxygen atom, R1 represents a cyano group, a lower alkoxycarbonyl group, a lower alkoxycarbonylamino group, a lower alkylsulfonylamino group, a lower alkanoyl or lower alkylsulfonyl group which may be substituted by a halogen atom, a 1-ureido group, a halo-substituted lower alkyl group or a 2-pyrrolylimino group, R2 and R3 are the same or different and each independently represents a hydrogen atom or a lower alkyl group and m stands for an integer of 2 to 4, or a salt thereof; and a medicament comprising the compound as an effective ingredient. The compound of the invention is useful as a preventive and therapeutic agent for epigastric dyscomfort, nausea, vomiting, heartburn, anorexia, bellyache, abdominal flatulence, chronic gastritis or the like.

  本发明涉及由下式(I)代表的取代苯甲酰氨基噻唑衍生物： 其中 X 代表可被低级烷基或氧原子取代的亚氨基，R1 代表氰基、低级烷氧基羰基、低级烷氧基羰基氨基、低级烷基磺酰基氨基、可被卤素原子取代的低级烷酰基或低级烷基磺酰基、1-脲基、卤代低级烷基或 2-吡咯基亚胺基，R2 和 R3 相同或不同，各自独立地代表氢原子或低级烷基，m 代表 2 至 4 的整数，或其盐；以及包含本发明化合物作为有效成分的药物。本发明的化合物可作为上腹不适、恶心、呕吐、胃灼热、厌食、肚痛、腹部胀气、慢性胃炎或类似疾病的预防和治疗药物。
• US6121301A
  申请人：——

  公开号：US6121301A

  公开（公告）日：2000-09-19