3,5-bis(3,4-dihydroxyphenyl)-1,2,4-triazole | 1147315-24-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 3,5-bis(3,4-dihydroxyphenyl)-1,2,4-triazole
• 英文别名: 4-[3-(3,4-dihydroxyphenyl)-1H-1,2,4-triazol-5-yl]benzene-1,2-diol
• CAS: 1147315-24-9
• 化学式: C₁₄H₁₁N₃O₄
• 分子量: 285.259
• InChiKey: GIPLCNDRNRQLCZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  123
• 氢给体数：
  5
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  3,5-bis(1,3-benzodioxol-5-yl)-1H-1,2,4-triazole 在 三溴化硼 、 甲醇 作用下， 以 二氯甲烷 为溶剂， 反应 27.0h， 以52%的产率得到3,5-bis(3,4-dihydroxyphenyl)-1,2,4-triazole
  参考文献：
  名称：

  Compounds, Compositions, and Methods for the Treatment of Beta-Amyloid Diseases and Synucleinopathies

  摘要：

  二羟基芳基化合物及其药学上可接受的酯类，其合成方法，含有它们的制药组合物，以及它们在β-淀粉样蛋白病（如阿尔茨海默病中观察到的）和突触核蛋白病（如帕金森病中观察到的）治疗中的用途，以及用于制造这种治疗药物。

  公开号：

  US20100331380A1

文献信息

• Compounds, Compositions and Methods for the Treatment of Islet Amyloid Polypeptide (IAPP) Accumulation in Diabetes
  申请人：Lake Thomas

  公开号：US20090227647A1

  公开（公告）日：2009-09-10

  Dihydroxyaryl compounds and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of IAPP or amylin fibril diseases, and the manufacture of medicaments for such treatment.

  二羟基芳基化合物和药用可接受的酯，它们的合成，含有它们的药物组合物，以及它们在治疗IAPP或淀粉样蛋白纤维病中的用途，以及用于制造用于这种治疗的药物。
• Compounds, Compositions and Methods for the Treatment of Beta-Amyloid Diseases and Synucleinopathies
  申请人：Esposito Luke A.

  公开号：US20090111863A1

  公开（公告）日：2009-04-30

  Dihydroxyaryl compounds and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of β-amyloid diseases, such as observed in Alzheimer's disease, and synucleinopathies, such as observed in Parkinson's disease, and the manufacture of medicaments for such treatment.

  二羟基芳基化合物及其药学上可接受的酯，其合成方法，包含它们的药物组合物，以及它们在β-淀粉样蛋白疾病（如阿尔茨海默病中所观察到的）和突触核蛋白病（如帕金森病中所观察到的）的治疗中的使用，以及用于制造这种治疗药物。
• COMPOUNDS, COMPOSITIONS, AND METHODS FOR THE TREATMENT OF BETA-AMYLOID DISEASES AND SYNUCLEINOPATHIES
  申请人：Esposito Luke A.

  公开号：US20120252858A1

  公开（公告）日：2012-10-04

  Dihydroxyaryl compounds and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of β-amyloid diseases, such as observed in Alzheimer's disease, and synucleinopathies, such as observed in Parkinson's disease, and the manufacture of medicaments for such treatment.

  二羟基芳基化合物及其药学上可接受的酯类，其合成，含有它们的制药组合物，以及它们在治疗β-淀粉样病变，如阿尔茨海默病中观察到的和突触核蛋白病，如帕金森病中观察到的使用，以及用于制造此类治疗药物。
• COMPOUNDS, COMPOSITIONS AND METHODS FOR THE TREATMENT OF beta-AMYLOID DISEASES AND SYNUCLEINOPATHIES
  申请人：Proteotech Inc.

  公开号：EP2328417A1

  公开（公告）日：2011-06-08
• Compounds and Compositions for Use as Modulators of Tau Aggregation and Alleviation of Tauopathies
  申请人：Snow Alan D.

  公开号：US20110144124A1

  公开（公告）日：2011-06-16

  This invention relates to the use of bis- and tris-dihydroxyaryl compounds as well as sulfonamides, heteroaryls, tricycloalkyl and their analogs and pharmaceutically acceptable salts, for modulating tau aggregation and alleviating tauopathies, such as Alzheimer's disease (AD), Pick's disease (PiD), progressive supranuclear palsy (PSP), corticobasal degeneration (CBD) and familial frontotemporal dementia/Parkinsonism linked to chromosome 17 (FTDP-17), amyotrophic lateral sclerosis/Parkinsonism-dementia complex, argyrophilic grain dementia, dementia pugilistic, diffuse neurofibrillary tangles with calcification, progressive subcortical gliosis and tangle only dementia.