cis-4,5-dihydro-4-isopropyl-5-methyl-2(3H)-furanone | 112423-40-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酯类
• 英文名称: cis-4,5-dihydro-4-isopropyl-5-methyl-2(3H)-furanone
• 英文别名: (4S,5R)-5-methyl-4-propan-2-yloxolan-2-one
• CAS: 112423-40-2
• 化学式: C₈H₁₄O₂
• 分子量: 142.198
• InChiKey: GNHWYEYAYRDMDQ-RQJHMYQMSA-N

物化性质

• 沸点：
  216.3±8.0 °C(Predicted)
• 密度：
  0.958±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  3-formyl-4-methyl-pentanoic acid methyl ester 、 trichloromethyl-Titanium 以 乙醚 、 水 为溶剂， 生成 cis-4,5-dihydro-4-isopropyl-5-methyl-2(3H)-furanone 、 trans-4,5-dihydro-4-isopropyl-5-methyl-2(3H)-furanone
  参考文献：
  名称：

  Kunz, Thomas; Reissig, Hans-Ulrich, Angewandte Chemie, 1988, vol. 100, # 2, p. 297 - 298

  摘要：

  DOI：

文献信息

• Kunz, Thomas; Janowitz, Agnes; Reissig, Hans-Ulrich, Chemische Berichte, 1989, vol. 122, p. 2165 - 2176
  作者：Kunz, Thomas、Janowitz, Agnes、Reissig, Hans-Ulrich

  DOI：——

  日期：——
• BICYCLIC AND TRICYCLIC DERIVATIVES AS THROMBIN RECEPTOR ANTAGONISTS
  申请人：Chackalamannil Samuel

  公开号：US20120157403A1

  公开（公告）日：2012-06-21

  Heterocyclic-substituted tricyclics of the formula or a pharmaceutically acceptable salt or solvate of said compound, isomer or racemic mixture wherein represents an optional double bond, the dotted line is optionally a bond or no bond, resulting in a double bond or a single bond, as permitted by the valency requirement and wherein E, A, G M, Het, B, X, R 3 , R 10 , R 11 , R 32 and R 33 are herein defined and the remaining substituents are as defined in the specification, are disclosed, as well as pharmaceutical compositions containing them and a method of treating diseases associated with thrombosis, atherosclerosis, restenosis, hypertension, angina pectoris, arrhythmia, heart failure, and cancer by administering said compounds. Combination therapy with other cardiovascular agents is also claimed.