3-nitroso-2-(3'-(trifluoromethyl)phenyl)imidazo[1,2-a]pyridine | 1312164-35-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 3-nitroso-2-(3'-(trifluoromethyl)phenyl)imidazo[1,2-a]pyridine
• CAS: 1312164-35-4
• 化学式: C₁₄H₈F₃N₃O
• 分子量: 291.232
• InChiKey: ADWDESWJLDZBAM-UHFFFAOYSA-N

反应信息

• 作为产物：
  描述：

  2-(3-trifluoromethyl-phenyl)-imidazo[1,2-a] pyridine 在 亚硝酸 作用下， 以90%的产率得到3-nitroso-2-(3'-(trifluoromethyl)phenyl)imidazo[1,2-a]pyridine
  参考文献：
  名称：

  Anti-anxiety and sedative profile evaluation of imidazo[1,2-a]pyridine derivatives

  摘要：

  AbstractThree imidazo[1,2‐a]pyridine‐3‐nitrosated (L‐1, L‐2, L‐3) and a 3‐formyl imidazo[1,2‐a]pyridine thiosemicarbazone (L‐4) were synthesized and evaluated for their effects in the elevated plus maze, burying behavior test, rotarod performance, the horizontal wire test, and locomotor activity. L‐2 and L‐3 increased the percent time spent in the open arms of the plus maze at doses of 1 and 2 mg/kg without modifying the number of total entries. In addition, L‐2 and L‐3 (1 mg/kg) increased the number of open arm entries indicating anxiolytic‐like activity at this dose. In the burying behavioral test, L‐1 (2–8 mg/kg), L‐2 (8 mg/kg), and L‐3 (4 and 8 mg/kg), induced a clear reduction in cumulative burying behavior, without modifying burying behavior latency, thus reducing experimental anxiety. In the rotarod test, L‐1 and L‐2 impaired rotarod performance only at the highest evaluated dose (64 mg/kg) at which reduction of motor activity was observed and thereby no conclusions about myorelaxant effects can be proposed. All compounds showed a clear sedative effect and corresponding ED50 values were obtained. Results indicate that compounds L‐1, L‐2, and L‐3 show a sedative and an anxiolytic profile. Drug Dev Res 71:371–381, 2010. © 2010 Wiley‐Liss, Inc.

  DOI：

  10.1002/ddr.20382