[3-(4-fluorophenyl)-6-methylpyrazolo[1,5-a]pyridin-2-yl]methanol | 1276126-95-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: [3-(4-fluorophenyl)-6-methylpyrazolo[1,5-a]pyridin-2-yl]methanol
• CAS: 1276126-95-4
• 化学式: C₁₅H₁₃FN₂O
• 分子量: 256.279
• InChiKey: CAEFWVWMMQJDEQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  37.5
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• INDOLIZINE INHIBITORS OF 5-LIPOXYGENASE
  申请人：Roppe Jeffrey Roger

  公开号：US20120214840A1

  公开（公告）日：2012-08-23

  Described herein are compounds and pharmaceutical compositions containing such compounds, which inhibit the activity of 5-lipoxygenase (5-LO). Also described herein are methods of using such 5-LO inhibitors, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other leukotriene-dependent or leukotriene mediated conditions, diseases, or disorders.

  本文所述的是含有这些化合物的药物组合物，这些化合物抑制5-脂氧化酶（5-LO）的活性。本文还描述了使用这种5-LO抑制剂的方法，单独或与其他化合物联合使用，用于治疗呼吸系统、心血管系统和其他依赖或介导白三烯的情况、疾病或障碍。
• [EN] INDOLIZINE INHIBITORS OF 5-LIPOXYGENASE<br/>[FR] INHIBITEURS DE 5-LIPOXYGÉNASE À BASE D'INDOLIZINE
  申请人：AMIRA PHARMACEUTICALS INC

  公开号：WO2011038097A2

  公开（公告）日：2011-03-31

  Described herein are compounds and pharmaceutical compositions containing such compounds, which inhibit the activity of 5-lipoxygenase (5-LO). Also described herein are methods of using such 5-LO inhibitors, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other leukotriene-dependent or leukotriene mediated conditions, diseases, or disorders.