ethyl-(2-acetoxy-ethyl)-phosphinic acid butyl ester | 115050-11-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物
• 英文名称: ethyl-(2-acetoxy-ethyl)-phosphinic acid butyl ester
• 英文别名: Aethyl-(2-acetoxy-aethyl)-phosphinsaeure-butylester；2-[Butoxy(ethyl)phosphoryl]ethyl acetate
• CAS: 115050-11-8
• 化学式: C₁₀H₂₁O₄P
• 分子量: 236.248
• InChiKey: KPIHJUXWGNZHEQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  15
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• Method for Producing Mono-Hydroxy-Functionalized Dialkylphosphinic Acids, Esters and Salts Using a Vinyl Ester of a Carobxylic Acid and The Use Thereof
  申请人：Hill Michael

  公开号：US20110237722A1

  公开（公告）日：2011-09-29

  The invention relates to a method for producing mono-hydroxy-functionalized dialkylphosphinic acids, esters and salts. The method is characterized by the following steps: a) reacting a phosphinic acid source (I) with olefins (IV) in the presence of a catalyst A to give an alkylphosphonous acid, the salt or the ester (II) thereof, b) reacting the alkylphosphonous acid so obtained, the salt or the ester (II) thereof with a vinyl ester of a carboxylic acid of formula (V) in the presence of a catalyst B to give a mono-functionalized dialkylphosphinic acid derivative (VI) and c) reacting the mono-functionalized dialkylphosphinic acid derivative (VI) so obtained in the presence of a catalyst C to give a mono-hydroxy-functionalized dialkylphosphinic acid derivative (III), wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 are the same or different and independently of each other inter alia represent H, C 1 -C 18 alkyl, C 6 -C 18 aryl, C 6 -C 18 aralkyl, C 6 -C 18 alkylaryl and X represents H, C 1 -C 18 alkyl, C 6 -C 18 aryl, C 6 -C 18 aralkyl C 6 -C 18 alkylaryl, Mg, Ca, Al, Sb, Sn, Ge, Ti, Fe, Zr, Zn, Ce, Bi, Sr, Mn, Cu, Ni, Li, Na, K and/or a protonated nitrogen base and the catalyst A is a transition metal and/or a transition metal compound and/or a catalyst system which is composed of a transition metal and/or a transition metal compound and at least one ligand, and the catalyst B is a peroxide-forming compound and/or a peroxo compound and/or an azo compound, and the catalyst C is an acid or a base.

  该发明涉及一种制备单羟基功能化二烷基膦酸、酯和盐的方法。该方法包括以下步骤：a）在催化剂A的存在下，将膦酸源（I）与烯烃（IV）反应，得到烷基膦酸、盐或其酯（II），b）在催化剂B的存在下，将所得的烷基膦酸、盐或其酯（II）与式（V）的羧酸乙烯酯反应，得到单功能化的二烷基膦酸衍生物（VI），c）在催化剂C的存在下，将所得的单功能化的二烷基膦酸衍生物（VI）反应，得到单羟基功能化的二烷基膦酸衍生物（III）。其中，R1、R2、R3、R4、R5、R6、R7可以相同也可以不同，独立地表示H、C1-C18烷基、C6-C18芳基、C6-C18芳基烷基、C6-C18烷基芳基，X表示H、C1-C18烷基、C6-C18芳基、C6-C18芳基烷基、C6-C18烷基芳基、Mg、Ca、Al、Sb、Sn、Ge、Ti、Fe、Zr、Zn、Ce、Bi、Sr、Mn、Cu、Ni、Li、Na、K和/或质子化氮碱，催化剂A是过渡金属和/或过渡金属化合物和/或由过渡金属和/或过渡金属化合物和至少一种配体组成的催化剂体系，催化剂B是过氧化物形成化合物和/或过氧化物和/或偶氮化合物，催化剂C是酸或碱。
• US4960919A
  申请人：——

  公开号：US4960919A

  公开（公告）日：1990-10-02
• US9068119B2
  申请人：——

  公开号：US9068119B2

  公开（公告）日：2015-06-30