2-(3,4-dimethoxyphenyl)-6,7-dihydropyrrolo[2,3-c]azepine-4,8(1H,5H)-dione | 1360788-51-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: 2-(3,4-dimethoxyphenyl)-6,7-dihydropyrrolo[2,3-c]azepine-4,8(1H,5H)-dione
• 英文别名: 2-(3,4-Dimethoxyphenyl)-1,5,6,7-tetrahydropyrrolo[2,3-c]azepine-4,8-dione；2-(3,4-dimethoxyphenyl)-1,5,6,7-tetrahydropyrrolo[2,3-c]azepine-4,8-dione
• CAS: 1360788-51-7
• 化学式: C₁₆H₁₆N₂O₄
• 分子量: 300.314
• InChiKey: RMASMKKPZUYVKP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.02
• 重原子数：
  22.0
• 可旋转键数：
  3.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  80.42
• 氢给体数：
  2.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  2-(3,4-dimethoxyphenyl)-6,7-dihydropyrrolo[2,3-c]azepine-4,8(1H,5H)-dione 在 ammonium hydroxide 、 四氯化钛 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 38.75h， 生成 (Z)-4-(2-amino-4-oxo-1H-imidazol-5(4H)-ylidene)-2-(3,4-dimethoxyphenyl)-4,5,6,7-tetrahydropyrrolo[2,3-c]azepin-8(1H)-one
  参考文献：
  名称：

  Synthesis and evaluation of debromohymenialdisine-derived Chk2 inhibitors

  摘要：

  Natural products have been the subject of interest for drug discovery and as tools for understanding the underlying cellular pathways in various diseases. We present herein the synthesis and evaluation of new analogs of the marine sponge metabolite, debromohymenialdisine, as checkpoint kinase 2 (Chk2) inhibitors. We illustrate herein that slight modifications to the natural product scaffold can induce strong selectivity for Chk2 over Chk1. These Chk2 inhibitors can serve as drug templates or molecular tools to gain insight in Chk2 mediated radioprotection. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2011.12.054
• 作为产物：
  描述：

  2-溴-6,7-二氢-1h,5h-吡咯并[2,3-c]氮杂烷-4,8-二酮 、 3,4-二甲氧基苯硼酸 在 四(三苯基膦)钯 、 sodium carbonate 作用下， 以 乙醇 、 水 、 甲苯 为溶剂， 反应 18.0h， 以82%的产率得到2-(3,4-dimethoxyphenyl)-6,7-dihydropyrrolo[2,3-c]azepine-4,8(1H,5H)-dione
  参考文献：
  名称：

  Synthesis and evaluation of debromohymenialdisine-derived Chk2 inhibitors

  摘要：

  Natural products have been the subject of interest for drug discovery and as tools for understanding the underlying cellular pathways in various diseases. We present herein the synthesis and evaluation of new analogs of the marine sponge metabolite, debromohymenialdisine, as checkpoint kinase 2 (Chk2) inhibitors. We illustrate herein that slight modifications to the natural product scaffold can induce strong selectivity for Chk2 over Chk1. These Chk2 inhibitors can serve as drug templates or molecular tools to gain insight in Chk2 mediated radioprotection. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2011.12.054