1,1-dimethylethyl 5-{5-acetyl-2-[(2-pyridinylmethyl)oxy]phenyl}-1,3-dihydro-2H-isoindole-2-carboxylate | 1398697-95-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1,1-dimethylethyl 5-{5-acetyl-2-[(2-pyridinylmethyl)oxy]phenyl}-1,3-dihydro-2H-isoindole-2-carboxylate
• 英文别名: Tert-butyl 5-[5-acetyl-2-(pyridin-2-ylmethoxy)phenyl]-1,3-dihydroisoindole-2-carboxylate
• CAS: 1398697-95-4
• 化学式: C₂₇H₂₈N₂O₄
• 分子量: 444.53
• InChiKey: FOWFMUQYYPQQTP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  33
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  68.7
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• NOVEL COMPOUNDS
  申请人：Atkinson Francis Louis

  公开号：US20120232061A1

  公开（公告）日：2012-09-13

  A compound of formula (I): or a salt thereof; which is an inhibitor of spleen tyrosine kinase (SYK) and therefore potentially of use in treating diseases resulting from inappropriate activation of mast cells, macrophages, and B-cells and related inflammatory responses and tissue damage, for instance inflammatory diseases and/or allergic conditions, in cancer therapy, specifically heme malignancies, and autoimmune conditions.

  化合物公式（I）或其盐；它是脾酪氨酸激酶（SYK）的抑制剂，因此可能用于治疗由肥大细胞、巨噬细胞和B细胞的不适当激活以及相关的炎症反应和组织损伤引起的疾病，例如炎症性疾病和/或过敏症，在癌症治疗中，特别是血液恶性肿瘤和自身免疫疾病。
• [EN] PYRIDINYL- AND PYRAZINYL -METHYLOXY - ARYL DERIVATIVES USEFUL AS INHIBITORS OF SPLEEN TYROSINE KINASE (SYK)<br/>[FR] DÉRIVÉS PYRDINYL- ET PYRAZINYL-MÉTHYLOXY-ARYLE UTILES EN TANT QU'INHIBITEURS DE LA TYROSINE KINASE DE LA RATE (SYK)
  申请人：GLAXO GROUP LTD

  公开号：WO2012123311A1

  公开（公告）日：2012-09-20

  A compound of formula (I) or a salt thereof; which is an inhibitor of spleen tyrosine kinase (SYK) and therefore potentially of use in treating diseases resulting from inappropriate activation of mast cells, macrophages, and B-cells and related inflammatory responses and tissue damage, for instance inflammatory diseases and/or allergic conditions, in cancer therapy, specifically heme malignancies, and autoimmune conditions.

  化合物的化学式（I）或其盐；它是脾酪氨酸激酶（SYK）的抑制剂，因此可能用于治疗由于肥大细胞、巨噬细胞和B细胞不适当激活引起的疾病，以及相关的炎症反应和组织损伤，例如炎症性疾病和/或过敏症状，在癌症治疗中，特别是血液恶性肿瘤和自身免疫疾病。
• PYRIDINYL- AND PYRAZINYL-METHYLOXY-ARYL DERIVATIVES USEFUL AS INHIBITORS OF SPLEEN TYROSINE KINASE (SYK)
  申请人：Atkinson Francis Louis

  公开号：US20140005177A1

  公开（公告）日：2014-01-02

  A compound of formula (I): or a salt thereof; which is an inhibitor of spleen tyrosine kinase (SYK) and therefore potentially of use in treating diseases resulting from inappropriate activation of mast cells, macrophages, and B-cells and related inflammatory responses and tissue damage, for instance inflammatory diseases and/or allergic conditions, in cancer therapy, specifically heme malignancies, and autoimmune conditions.

  式(I)的化合物或其盐；它是脾酪氨酸激酶（SYK）的抑制剂，因此可能用于治疗由于肥大细胞、巨噬细胞和B细胞的不适当活化以及相关的炎症反应和组织损伤引起的疾病，例如炎症性疾病和/或过敏性疾病，在癌症治疗中，特别是血液恶性肿瘤和自身免疫疾病中。
• PYRIDINYL- AND PYRAZINYL -METHYLOXY - ARYL DERIVATIVES USEFUL AS INHIBITORS OF SPLEEN TYROSINE KINASE (SYK)
  申请人：Glaxo Group Limited

  公开号：EP2937344A1

  公开（公告）日：2015-10-28

  A compound of formula (I): or a pharmaceutically acceptable salt thereof; which is an inhibitor of spleen tyrosine kinase (SYK) for use in the treatment of inflammatory diseases and/or allergic disorders such as dermatitis, mastocytosis or cutaneous lupus.

  式 (I) 的化合物： 或其药学上可接受的盐； 是一种脾脏酪氨酸激酶（SYK）抑制剂，可用于治疗炎症性疾病和/或过敏性疾病，如皮炎、肥大细胞增多症或皮肤狼疮。
• TREATMENT FOR VITILIGO
  申请人：GLAXO GROUP LIMITED

  公开号：US20180207172A1

  公开（公告）日：2018-07-26

  A method of treating vitiligo, including prophylaxis, in a subject in need thereof, comprising administering to said subject a pharmaceutically effective amount of a compound of Formula (I): wherein: X is CR 1 or N; Y is CH, C or N; R 1 is hydrogen, C 1-6 alkoxy or C 1-6 alkyl; R 2 is hydrogen, C 1-6 alkoxy, halo, —C(O)C 1-6 alkyl, CN, halo-C 1-6 alkyl or —C(O)NR 4 R 5 ; R 3 is hydrogen or C 1-6 alkoxy; R 4 is hydrogen or C 1-6 alkyl: R 5 is hydrogen or C 1-6 alkyl; and m and n are integers each independently selected from 1 and 2, or a pharmaceutically acceptable salt thereof.