(Z)-13-benzoylphenyl-9-tridecenoic acid (S)-(2,2-dimethyl-1,3-dioxolan-4-yl)methyl ester | 874140-89-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (Z)-13-benzoylphenyl-9-tridecenoic acid (S)-(2,2-dimethyl-1,3-dioxolan-4-yl)methyl ester
• 英文别名: [(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl (Z)-13-(4-benzoylphenyl)tridec-9-enoate
• CAS: 874140-89-3
• 化学式: C₃₂H₄₂O₅
• 分子量: 506.682
• InChiKey: WGFDFIAKADAVSK-JLTWWHCBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.9
• 重原子数：
  37
• 可旋转键数：
  17
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  61.8
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  (Z)-13-benzoylphenyl-9-tridecenoic acid (S)-(2,2-dimethyl-1,3-dioxolan-4-yl)methyl ester 在 盐酸 作用下， 以 1,4-二氧六环 为溶剂， 反应 4.0h， 以73%的产率得到1-((Z)-13-(4-benzoylphenyl)-9-tridecenoyl)-sn-glycerol
  参考文献：
  名称：

  Synthesis of Photoactivatable Analogues of Lysophosphatidic Acid and Covalent Labeling of Plasma Proteins

  摘要：

  Lysophosphatidic acids bearing a benzophenone group in either the sn-1 or sn-2 chain of an oleoyl-type ester or oleyl-type ether chain and P-32 in the phosphate group were synthesized. The benzophenone moiety was introduced by selective hydroboration of the double bond of enyne 11 at low temperature, followed by a Suzuki reaction with 4-bromobenzophenone. The key intermediates for the preparation of ester-linked lysophosphatidic acid (LPA) I and 3 were obtained in one pot by a modified DIBAL-H reduction of orthoformate intermediate 22. These probes were shown to covalently modify a single protein target in rat plasma containing albumin and several protein targets in rat plasma containing a low level of albumin.

  DOI：

  10.1021/jo052030w
• 作为产物：
  描述：

  2-(9-癸炔-1-基氧基)四氢-2H-吡喃 在 Lindlar's catalyst 4-二甲氨基吡啶 、 重铬酸吡啶 、 9-borabicyclo[3.3.1]nonane dimer 、 正丁基锂 、 氢气 、 4-甲基苯磺酸吡啶 、 N,N'-二环己基碳二亚胺 作用下， 以 四氢呋喃 、 甲醇 、 正己烷 、 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 93.0h， 生成 (Z)-13-benzoylphenyl-9-tridecenoic acid (S)-(2,2-dimethyl-1,3-dioxolan-4-yl)methyl ester
  参考文献：
  名称：

  Synthesis of Photoactivatable Analogues of Lysophosphatidic Acid and Covalent Labeling of Plasma Proteins

  摘要：

  Lysophosphatidic acids bearing a benzophenone group in either the sn-1 or sn-2 chain of an oleoyl-type ester or oleyl-type ether chain and P-32 in the phosphate group were synthesized. The benzophenone moiety was introduced by selective hydroboration of the double bond of enyne 11 at low temperature, followed by a Suzuki reaction with 4-bromobenzophenone. The key intermediates for the preparation of ester-linked lysophosphatidic acid (LPA) I and 3 were obtained in one pot by a modified DIBAL-H reduction of orthoformate intermediate 22. These probes were shown to covalently modify a single protein target in rat plasma containing albumin and several protein targets in rat plasma containing a low level of albumin.

  DOI：

  10.1021/jo052030w

文献信息

• Synthesis of Photoactivatable Analogues of Lysophosphatidic Acid and Covalent Labeling of Plasma Proteins
  作者：Zaiguo Li、Daniel L. Baker、Gabor Tigyi、Robert Bittman

  DOI：10.1021/jo052030w

  日期：2006.1.1

  Lysophosphatidic acids bearing a benzophenone group in either the sn-1 or sn-2 chain of an oleoyl-type ester or oleyl-type ether chain and P-32 in the phosphate group were synthesized. The benzophenone moiety was introduced by selective hydroboration of the double bond of enyne 11 at low temperature, followed by a Suzuki reaction with 4-bromobenzophenone. The key intermediates for the preparation of ester-linked lysophosphatidic acid (LPA) I and 3 were obtained in one pot by a modified DIBAL-H reduction of orthoformate intermediate 22. These probes were shown to covalently modify a single protein target in rat plasma containing albumin and several protein targets in rat plasma containing a low level of albumin.