2-(1,2,3,4-tetrahydro-2-naphthalenyliden)-1-indanone | 1296863-23-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚满类
• 英文名称: 2-(1,2,3,4-tetrahydro-2-naphthalenyliden)-1-indanone
• 英文别名: 2-(3,4-Dihydronaphthalen-2-yl)-2,3-dihydroinden-1-one
• CAS: 1296863-23-4
• 化学式: C₁₉H₁₆O
• 分子量: 260.335
• InChiKey: NHHVMIWTGMMJFJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  20
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-(1,2,3,4-tetrahydro-2-naphthalenyliden)-1-indanone 、 溴甲苯 在 potassium tert-butylate 作用下， 以 乙醚 、 叔丁醇 为溶剂， 以54%的产率得到2-benzyl-2-(3,4-dihydro-2-naphthalenyl)-1-indanone
  参考文献：
  名称：

  Synthesis of novel mast cell-stabilising and anti-allergic 1,2,3,4-tetrahydro-1-naphthalenols and related compounds

  摘要：

  In a continuation of our studies into indan and tetralin systems as novel modulators of allergic and inflammatory phenomena, we have extended our work to include dimers linked via C-C bonds. Of these compounds, 2-Benzyl-2-[2-phenyl-1-ethenyl]-1,2,3,4-tetrahydro-1-naphthalenol 12 exhibited most promising activity both in vitro and in vivo. (C) 2011 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2011.01.073
• 作为产物：
  描述：

  1-trimethylsilyloxy-3H-indene 、 2-Tetralone ethylene ketal 在 四氯化锡 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 以31%的产率得到2-(1,2,3,4-tetrahydro-2-naphthalenyliden)-1-indanone
  参考文献：
  名称：

  Synthesis of novel mast cell-stabilising and anti-allergic 1,2,3,4-tetrahydro-1-naphthalenols and related compounds

  摘要：

  In a continuation of our studies into indan and tetralin systems as novel modulators of allergic and inflammatory phenomena, we have extended our work to include dimers linked via C-C bonds. Of these compounds, 2-Benzyl-2-[2-phenyl-1-ethenyl]-1,2,3,4-tetrahydro-1-naphthalenol 12 exhibited most promising activity both in vitro and in vivo. (C) 2011 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2011.01.073

文献信息

• Synthesis of novel mast cell-stabilising and anti-allergic 1,2,3,4-tetrahydro-1-naphthalenols and related compounds
  作者：James W. Barlow、Aengus P. McHugh、Orla Woods、John J. Walsh

  DOI：10.1016/j.ejmech.2011.01.073

  日期：2011.5

  In a continuation of our studies into indan and tetralin systems as novel modulators of allergic and inflammatory phenomena, we have extended our work to include dimers linked via C-C bonds. Of these compounds, 2-Benzyl-2-[2-phenyl-1-ethenyl]-1,2,3,4-tetrahydro-1-naphthalenol 12 exhibited most promising activity both in vitro and in vivo. (C) 2011 Elsevier Masson SAS. All rights reserved.