| 1331749-35-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• CAS: 1331749-35-9
• 化学式: C₅₂H₉₀N₄O₃₄S₂
• 分子量: 1379.43
• InChiKey: QHKWYXPPESNWLH-NVXKDERQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -12.96
• 重原子数：
  92.0
• 可旋转键数：
  17.0
• 环数：
  21.0
• sp3杂化的碳原子比例：
  0.96
• 拓扑面积：
  596.79
• 氢给体数：
  25.0
• 氢受体数：
  38.0

反应信息

• 作为产物：
  描述：

  2-亚氨基硫烷盐酸盐 、 mono-6-deoxy-6-(2-aminoethylamino)-β-cyclodextrin 反应 3.0h， 生成
  参考文献：
  名称：

  Leading Neuroblastoma Cells To Die by Multiple Premeditated Attacks from a Multifunctionalized Nanoconstruct

  摘要：

  To conquer complex and devastating diseases such as cancer, more coordinated and combined attack strategies are needed. We suggest that these can be beautifully achieved by using nanoconstruct design. We present an example showing that neuroblastoma cells are selectively killed by a nanoconstruct that specifically targets neuroblastoma cells, pushes cells to the vulnerable phase of the cell cycle, and greatly enhances radiation-induced cell death. The success of this multipronged attack approach launched by cell-embedded nanoconstructs demonstrates the power and flexibility of nanotechnology in treating cancer, a difficult task for a small molecule.

  DOI：

  10.1021/ja206118a