[EN] PYRIDINE COMPOUNDS AS SODIUM CHANNEL BLOCKERS<br/>[FR] COMPOSÉS PYRIDINES COMME BLOQUEURS DES CANAUX SODIQUES
申请人:PURDUE PHARMA LP
公开号:WO2012007836A1
公开(公告)日:2012-01-19
The invention relates to substituted pyridine compounds of Formula I: (I) or a pharmaceutically acceptable salt, prodrug, or solvate thereof, wherein A1, X, A2, R1a, R1b, R1c, G, and z are defined as set forth in the specification. The invention is also directed to the use of compounds of Formula I to treat a disorder responsive to the blockade of sodium channels. Compounds of the present invention are especially useful for treating pain.
该发明涉及公式I的取代吡啶化合物:(I)或其药学上可接受的盐、前药或溶剂化合物,其中A1、X、A2、R1a、R1b、R1c、G和z的定义如规范中所述。该发明还涉及利用公式I的化合物治疗对钠通道阻滞有响应的疾病。本发明的化合物特别适用于治疗疼痛。