Boc-LYP2 | 1333111-61-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 肽模拟物
• 英文名称: Boc-LYP2
• CAS: 1333111-61-7
• 化学式: C₂₅H₄₂N₄O₅
• 分子量: 478.632
• InChiKey: RNFSGDAVFQFGIG-HKBOAZHASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.69
• 重原子数：
  34.0
• 可旋转键数：
  12.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  120.0
• 氢给体数：
  4.0
• 氢受体数：
  6.0

反应信息

• 作为反应物：
  描述：

  Boc-LYP2 在 盐酸 作用下， 以 乙酸乙酯 为溶剂， 以96%的产率得到LYP2
  参考文献：
  名称：

  Synthesis and activity evaluation of a new bestatin derivative LYP2 as an aminopeptidase N inhibitor

  摘要：

  As a ubiquitous enzyme overexpressed on the epithelium of the tumor, aminopeptidase N (APN) plays important roles in the angiogenesis and metastasis of the tumor. Bestatin as an effective inhibitor against APN is used in the ancillary treatment of various cancers. In this study, we modified the structure of a bestatin derivative LYP reported in our former study to provide a new bestatin derivative LYP2 with enhanced stability. We also tested the inhibitive activity of LYP2, which retained good efficacy in vitro and in vivo towards APN. Anti-Cancer Drugs 22:99-103 (C) 2011 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.

  DOI：

  10.1097/cad.0b013e32833ab78a
• 作为产物：
  描述：

  乌苯美司 在 1-羟基苯并三唑 、 N,N'-二环己基碳二亚胺 、 sodium hydroxide 作用下， 以 四氢呋喃 为溶剂， 反应 32.0h， 生成 Boc-LYP2
  参考文献：
  名称：

  Synthesis and activity evaluation of a new bestatin derivative LYP2 as an aminopeptidase N inhibitor

  摘要：

  As a ubiquitous enzyme overexpressed on the epithelium of the tumor, aminopeptidase N (APN) plays important roles in the angiogenesis and metastasis of the tumor. Bestatin as an effective inhibitor against APN is used in the ancillary treatment of various cancers. In this study, we modified the structure of a bestatin derivative LYP reported in our former study to provide a new bestatin derivative LYP2 with enhanced stability. We also tested the inhibitive activity of LYP2, which retained good efficacy in vitro and in vivo towards APN. Anti-Cancer Drugs 22:99-103 (C) 2011 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.

  DOI：

  10.1097/cad.0b013e32833ab78a