N-(piperidin-1-yl)-2-(1,4-dioxaspiro[4.5]decan-8-yl)ethan-1-imine | 1161202-86-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: N-(piperidin-1-yl)-2-(1,4-dioxaspiro[4.5]decan-8-yl)ethan-1-imine
• CAS: 1161202-86-3
• 化学式: C₁₅H₂₆N₂O₂
• 分子量: 266.384
• InChiKey: PKHSCUYSYZHGBI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.78
• 重原子数：
  19.0
• 可旋转键数：
  3.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  34.06
• 氢给体数：
  0.0
• 氢受体数：
  4.0

反应信息

• 作为产物：
  描述：

  8-(1,3-Dioxolan-2-ylmethyl)-1,4-dioxaspiro[4.5]decane 、 1-氨基哌啶 在 2,4,6-三甲基吡啶 、 三乙基硅基三氟甲磺酸酯 作用下， 以 二氯甲烷 为溶剂， 反应 0.5h， 以42%的产率得到N-(piperidin-1-yl)-2-(1,4-dioxaspiro[4.5]decan-8-yl)ethan-1-imine
  参考文献：
  名称：

  Organic Chemistry Using Weakly Electrophilic Salts: The Reaction with Nitrogen Nucleophiles

  摘要：

  The reaction of electrophilic salts, which were obtained by the treatment of acetals with TESOTf*center dot 2,4,6-collidine, with nitrogen nucleophiles was studied in detail. Treatment of the salts with potassium phthalimide afforded the corresponding N,O-acetals in good yields. The use of hydrazine in place of potassium phthalimide gave the corresponding hydrazones. The reaction is very mild and chemoselective, and acid-labile functional groups can tolerate these conditions.

  DOI：

  10.3987/com-08-s(d)69