N,N-dimethyl-N'-benzyl-1,2-cyclohexanediamine | 620597-07-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N,N-dimethyl-N'-benzyl-1,2-cyclohexanediamine
• 英文别名: 1-N-benzyl-2-N,2-N-dimethylcyclohexane-1,2-diamine
• CAS: 620597-07-1
• 化学式: C₁₅H₂₄N₂
• 分子量: 232.369
• InChiKey: NPZHMJAKYUBHGV-UHFFFAOYSA-N

物化性质

• 沸点：
  337.1±35.0 °C(Predicted)
• 密度：
  0.99±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  15.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  trans-(-)-2-(dimethylamino)cyclohexanol 、 sodium;hydride 、 甲基磺酰氯 、 苄胺 在 sodium hydroxide 、 乙醚 、 盐酸 、 水 、 magnesium sulfate 作用下， 以 四氢呋喃 为溶剂， 反应 20.75h， 以gave 61 g的产率得到N,N-dimethyl-N'-benzyl-1,2-cyclohexanediamine
  参考文献：
  名称：

  Analgesic N-(2-(furylmethylamino and 2 -thienylmethylamino)cyclo

  摘要：

  公式为##STR1##的顺式和反式N-(2-氨基环脂族)苯甲酰胺化合物，例如，N-甲基-N-[2-[(2-呋喃甲基)甲基氨基]环己基]-3,4-二氯苯甲酰胺及其药学上可接受的盐，已被发现具有强效的镇痛活性，包含这些化合物的制剂在制药剂量单位形式中对于缓解温血动物的疼痛以及使用这些制剂缓解动物疼痛的方法也被揭示。还揭示了制备这些化合物的过程。

  公开号：

  US04153717A1

文献信息

• 2-Aminocycloaliphatic amide compounds
  申请人：The Upjohn Company

  公开号：US04145435A1

  公开（公告）日：1979-03-20

  Cis- and trans-N-(2-aminocycloaliphatic)-2-arylacetamide derivative compounds of the formula ##STR1## e.g., N-\x9b2-(N', \n" N'-dimethylamino)cyclohexyl!-N-methyl-2-(4-bromophenyl)acetamide and trans-N-methyl-N-\x9b2-(1-pyrrolidinyl)cyclohexyl!acetamide, \n' 2-(3,4-dichlorophenyl) and their pharmaceutically acceptable salts, have been found to have potent analgesic activity, and the preferred compounds have in addition only low to moderate apparent physical dependence liability, compared to morphine and methadone. As analgesics they would be useful also as antitussives. Processes for preparation of these compounds are also disclosed. This invention also includes compositions containing these compounds useful in pharmaceutical dosage unit form for alleviating pain in humans and animals, as well as methods for alleviating pain in animals and humans with these compositions.

  式子为##STR1##的顺式和反式N-(2-氨基环脂肪基)-2-芳基乙酰胺衍生物化合物，例如N-\x9b2-(N'，\n" N'-二甲基氨基)环己基!-N-甲基-2-(4-溴苯基)乙酰胺和反式N-甲基-N-\x9b2-(1-吡咯烷基)环己基!乙酰胺，2-(3,4-二氯苯基)及其药物可接受的盐，已发现具有强效镇痛活性，并且与吗啡和美沙酮相比，优选化合物仅具有低至中度的明显身体依赖性。作为镇痛剂，它们也可以作为止咳剂使用。还公开了制备这些化合物的方法。本发明还包括含有这些化合物的组合物，其以制药剂量形式对于缓解人和动物的疼痛有用，以及使用这些组合物缓解动物和人的疼痛的方法。
• Analgesic N-(2-aminocyclo aliphatic)cyanobenzamides
  申请人：The Upjohn Company

  公开号：US04148914A1

  公开（公告）日：1979-04-10

  Cis- and trans-N-(2-aminocycloaliphatic)benzamide compounds of the formula ##STR1## e.g., N-methyl-N-[2-(N-pyrrolidinyl)cyclohexyl]-3,4-dichlorobenzamide, and their pharmaceutically acceptable salts, have been found to have potent analgesic activity, and compositions containing these compounds useful in pharmaceutical dosage unit form for alleviating pain in warm blooded animals, as well as methods for alleviating pain in animals with these compositions. Processes for preparing the compounds are also disclosed.

  式子为##STR1##的顺反异构体N-(2-氨基环脂肪基)苯甲酰胺化合物，例如N-甲基-N-[2-(N-吡咯烷基)环己基]-3,4-二氯苯甲酰胺及其药学上可接受的盐已被发现具有强效镇痛活性。包含这些化合物的制剂以药学剂量单位形式对于缓解温血动物的疼痛有用，同时还提供了使用这些制剂缓解动物疼痛的方法。还公开了制备这些化合物的方法。
• Analgesic N-(2-(furylmethylamino and 2 -thienylmethylamino)cyclo
  申请人：The Upjohn Company

  公开号：US04153717A1

  公开（公告）日：1979-05-08

  Cis- and trans-N-(2-aminocycloaliphatic)benzamide compounds of the formula ##STR1## e.g., N-methyl-N-[2-[(2-furylmethyl)methylamino]cyclohexyl]-3,4-dichlorobenzamid e, and their pharmaceutically acceptable salts, have been found to have potent analgesic activity, and compositions containing these compounds useful in pharmaceutical dosage unit form for alleviating pain in warm-blooded animals, as well as methods for alleviating pain in animals with these compositions. Processes for preparing the compounds are also disclosed.

  公式为##STR1##的顺式和反式N-(2-氨基环脂族)苯甲酰胺化合物，例如，N-甲基-N-[2-[(2-呋喃甲基)甲基氨基]环己基]-3,4-二氯苯甲酰胺及其药学上可接受的盐，已被发现具有强效的镇痛活性，包含这些化合物的制剂在制药剂量单位形式中对于缓解温血动物的疼痛以及使用这些制剂缓解动物疼痛的方法也被揭示。还揭示了制备这些化合物的过程。
• Analgesic N-{2-[N'-(2-furylmethyl and
  申请人：The Upjohn Company

  公开号：US04192885A1

  公开（公告）日：1980-03-11

  Cis- and trans-N-(2-aminocycloaliphatic)benzamide compounds of the formula ##STR1## e.g., N-methyl-N-[2-(N-pyrrolidinyl)cyclohexyl]-3,4-dichlorobenzamide, and their pharmaceutically acceptable salts, have been found to have potent analgesic activity, and compositions containing these compounds useful in pharmaceutical dosage unit form for alleviating pain in warm blooded animals, as well as methods for alleviating pain in animals with these compositions. Processes for preparing the compounds are also disclosed.

  式为##STR1##的顺式和反式N-(2-氨基环脂肪基)苯甲酰胺化合物，例如N-甲基-N-[2-(N-吡咯烷基)环己基]-3,4-二氯苯甲酰胺及其药学上可接受的盐，已被发现具有强效的镇痛活性，含有这些化合物的制剂以制药剂量形式用于缓解温血动物的疼痛，同时还公开了使用这些制剂缓解动物疼痛的方法。还公开了制备这些化合物的方法。
• Analgesic N-(2-aminocycloaliphatic)azidobenzamides
  申请人：The Upjohn Company

  公开号：US04179501A1

  公开（公告）日：1979-12-18

  Cis- and trans-N-(2-aminocycloaliphatic)benzamide compounds of the formula ##STR1## e.g., N-methyl-N-[2-(N-pyrrolidinyl)cyclohexyl]-3,4-dichlorobenzamide, and their pharmaceutically acceptable salts, have been found to have potent analgesic activity, and compositions containing these compounds useful in pharmaceutical dosage unit form for alleviating pain in warm blooded animals, as well as methods for alleviating pain in animals with these compositions. Processes for preparing the compounds are also disclosed.

  式子如下：##STR1##，例如，N-甲基-N-[2-(N-吡咯烷基)环己基]-3,4-二氯苯甲酰胺及其药学上可接受的盐已被发现具有很强的镇痛活性。含有这些化合物的组合物以制药剂量形式在温血动物中缓解疼痛，并提供了使用这些组合物缓解动物疼痛的方法。还公开了制备这些化合物的过程。