methyl 1-(4-bromophenyl)-4-phenyl-2-(p-tolyl)-1H-imidazole-5-carboxylate | 1536394-42-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: methyl 1-(4-bromophenyl)-4-phenyl-2-(p-tolyl)-1H-imidazole-5-carboxylate
• 英文别名: Methyl 3-(4-bromophenyl)-2-(4-methylphenyl)-5-phenylimidazole-4-carboxylate；methyl 3-(4-bromophenyl)-2-(4-methylphenyl)-5-phenylimidazole-4-carboxylate
• CAS: 1536394-42-9
• 化学式: C₂₄H₁₉BrN₂O₂
• 分子量: 447.331
• InChiKey: WKZIRABJEHHYSW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.2
• 重原子数：
  29
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  44.1
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  α-Azidozimtsaeuremethylester 、 对甲基苯甲醛 、 4-溴苯胺 在 erbium(III) triflate 作用下， 以 乙腈 为溶剂， 反应 0.17h， 以82%的产率得到methyl 1-(4-bromophenyl)-4-phenyl-2-(p-tolyl)-1H-imidazole-5-carboxylate
  参考文献：
  名称：

  Erbium Triflate Promoted Multicomponent Synthesis of Highly Substituted Imidazoles

  摘要：

  The synthesis of highly substituted imidazole derivatives has been achieved from various alpha-azido chalcones, aryl aldehydes, and anilines. This multicomponent protocol employs erbium triflate as a catalyst resulting in excellent yield of the imidazoles.

  DOI：

  10.1021/ol403456b

文献信息

• Erbium Triflate Promoted Multicomponent Synthesis of Highly Substituted Imidazoles
  作者：Kandasamy Rajaguru、Rajendran Suresh、Arumugam Mariappan、Shanmugam Muthusubramanian、Nattamai Bhuvanesh

  DOI：10.1021/ol403456b

  日期：2014.2.7

  The synthesis of highly substituted imidazole derivatives has been achieved from various alpha-azido chalcones, aryl aldehydes, and anilines. This multicomponent protocol employs erbium triflate as a catalyst resulting in excellent yield of the imidazoles.