4-氟-N-(4-碘苯)苯甲酰胺,97 | 326-03-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 4-氟-N-(4-碘苯)苯甲酰胺,97
• 英文名称: 4-fluoro-N-(4-iodophenyl)-benzamide
• 英文别名: 4-fluoro-N-(4-iodophenyl)benzamide；4-fluoro-benzoic acid-(4-iodo-anilide)；4-Fluor-benzoesaeure-(4-jod-anilid)
• CAS: 326-03-4
• 化学式: C₁₃H₉FINO
• mdl: MFCD00439116
• 分子量: 341.123
• InChiKey: XCQDZOSGJCUQMO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-氟-N-(4-碘苯)苯甲酰胺,97 在 Rh(acac)2(CO)2 copper(l) iodide 、 1,10-菲罗啉 、 硫酸 、 氢气 、 caesium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 80.0~100.0 ℃ 、6.0 MPa 条件下， 反应 140.0h， 生成 4-氟-N-(3-(1-甲基哌啶-4-基)-1H-吲哚-5-基)苯甲酰胺盐酸盐
  参考文献：
  名称：

  Synthesis of Pharmacologically Relevant Indoles with Amine Side Chains via Tandem Hydroformylation/Fischer Indole Synthesis

  摘要：

  The sequence of hydroformylation and Fischer indole synthesis starting from amino olefins and aryl hydrazines is described. In a convergent manner, the two units bearing pharmacologically relevant substituents are assembled in the final indolization step. This modular and diversity-oriented approach to tryptamines and homotryptamines can be conducted in water and allows synthesis of branched and nonbranched tryptamines as well as tryptamine-based pharmaceuticals such as the 5-HT1D agonist L 775 606.

  DOI：

  10.1021/jo050464l
• 作为产物：
  描述：

  对氟苯甲酸 在 五氯化磷 作用下， 生成 4-氟-N-(4-碘苯)苯甲酰胺,97
  参考文献：
  名称：

  Fukui et al., Nippon Kagaku Zasshi, 1958, vol. 79, p. 1428,1430

  摘要：

  DOI：

文献信息

• Observation of 3D isostructurality in halogen substituted N -benzoyl- N -phenylbenzamides
  作者：Rahul Shukla、Susanta K. Nayak、Deepak Chopra、M. Kishore Reddy、T.N. Guru Row

  DOI：10.1016/j.molstruc.2018.03.029

  日期：2018.7

  The occurrence of 3D isostructurality in six halogen substituted N-benzoyl-N-phenylbenzamides has been reported and this feature has been quantitatively analyzed in this study. 4-fluoro-N-(4-fluorobenzoyl) N-(fluorphenyl)benzamide (1) was observed to be isostructural with 2-fluoro-N-(2fluorobenzoyl) N-(4-fluorophenyl)benzamide (7), N-(4-bromophenyI)-2-fluoro-N-(2-fluorobenzoyl) benzamide (8) and 2

  已经报道了六种卤素取代的 N-苯甲酰基-N-苯基苯甲酰胺中出现 3D 同构性，并且在本研究中对该特征进行了定量分析。观察到 4-氟-N-(4-氟苯甲酰基) N-(氟苯基)苯甲酰胺 (1) 与 2-氟-N-(2氟苯甲酰基) N-(4-氟苯基)苯甲酰胺 (7)、N-( 4-溴苯基I)-2-氟-N-(2-氟苯甲酰基)苯甲酰胺(8)和2-氟-N-(2-氟苯甲酰基)N-(4-碘苯基)苯甲酰胺(9)。类似地，观察到 N-(4-氯苯基)-4-氟-N-(4-氟苯甲酰基)苯甲酰胺 (2) 和 N-(4-溴苯基)-4-氟-N-(4-氟苯甲酰基)苯甲酰胺 (3) 是同构的彼此。从结构相似性分析中可以清楚地看出，2/3 组 2] 中存在的 3D 超分子构建体与 1/7/8/9 组 1] 中观察到的那些相比更加相同。观察到两组同构分子中的分子堆积受几个 CH 中心点中心点中心点 O=C 相互作用的存在控制。除此之外
• Role of Hetero-Halogen (F···X, X = Cl, Br, and I) or Homo-Halogen (X···X, X = F, Cl, Br, and I) Interactions in Substituted Benzanilides
  作者：Susanta K. Nayak、M. Kishore Reddy、Tayur N. Guru Row、Deepak Chopra

  DOI：10.1021/cg101544z

  日期：2011.5.4

  A series of halogen-substituted benzanilides have been synthesized and characterized, and crystallization studies directed toward generation of polymorphs have been performed to delineate the importance of interactions involving halogens. The effect of halogen substitution on the molecular conformation and supramolecular packing has been investigated. The N-H center dot center dot center dot O H-bond is a key structure-directing element acting in conjunction with C-H center dot center dot center dot O and C-H center dot center dot center dot pi interactions. In addition, it is of importance to note that organic fluorine prefers Type I F center dot center dot center dot F contacts, whereas Cl, Br, and I prefer Type II contacts. Hetero-halogen center dot center dot center dot halogen interactions on the other hand are predominately of Type II geometry, and this is due to the greater polarizability of the electron density associated with the heavier halogens. It is of importance to evaluate the contributing role of these interactions in crystal structure packing and the co-operativity associated with such interactions in the solid state.
• Synthesis of Pharmacologically Relevant Indoles with Amine Side Chains via Tandem Hydroformylation/Fischer Indole Synthesis
  作者：Axel M. Schmidt、Peter Eilbracht

  DOI：10.1021/jo050464l

  日期：2005.7.1

  The sequence of hydroformylation and Fischer indole synthesis starting from amino olefins and aryl hydrazines is described. In a convergent manner, the two units bearing pharmacologically relevant substituents are assembled in the final indolization step. This modular and diversity-oriented approach to tryptamines and homotryptamines can be conducted in water and allows synthesis of branched and nonbranched tryptamines as well as tryptamine-based pharmaceuticals such as the 5-HT1D agonist L 775 606.
• Fukui et al., Nippon Kagaku Zasshi, 1958, vol. 79, p. 1428,1430
  作者：Fukui et al.

  DOI：——

  日期：——