1-(2,4-dimethoxy-phenyl)-2-piperidin-1-yl-ethanone | 4783-91-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-(2,4-dimethoxy-phenyl)-2-piperidin-1-yl-ethanone
• 英文别名: ω-Piperidino-2,4-dimethoxyacetophenon；1-(2,4-Dimethoxyphenacyl)-piperidin；1-(2,4-Dimethoxyphenyl)-2-piperidin-1-ylethanone
• CAS: 4783-91-9
• 化学式: C₁₅H₂₁NO₃
• 分子量: 263.337
• InChiKey: KBESRIYQCAEQGK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  38.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N-甲基马来酰亚胺 、 1-(2,4-dimethoxy-phenyl)-2-piperidin-1-yl-ethanone 在 tris(triphenylphosphine)rhodium(l) chloride 作用下， 以 甲苯 为溶剂， 反应 16.0h， 以55%的产率得到4-(2,4-dimethoxybenzoyl)-2-methyl-decahydro-1H-pyrrolo[3,4-a]indolizine-1,3-dione
  参考文献：
  名称：

  One pot rhodium catalysed three component dehydrogenation route to fused and spiro-heterocycles

  摘要：

  A three component rhodium-catalysed dehydrogenation reaction has been used for the synthesis of fused and spiro-heterocycles. The reaction proceeds in good yields with the formation of three new bonds and four stereocentres. Crown Copyright (C) 2015 Published by Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2015.10.007
• 作为产物：
  描述：

  哌啶 、 2-溴-2,4-二甲氧基苯乙酮 在 三乙胺 作用下， 以 甲苯 为溶剂， 生成 1-(2,4-dimethoxy-phenyl)-2-piperidin-1-yl-ethanone
  参考文献：
  名称：

  One pot rhodium catalysed three component dehydrogenation route to fused and spiro-heterocycles

  摘要：

  A three component rhodium-catalysed dehydrogenation reaction has been used for the synthesis of fused and spiro-heterocycles. The reaction proceeds in good yields with the formation of three new bonds and four stereocentres. Crown Copyright (C) 2015 Published by Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2015.10.007

文献信息

• US4705795A
  申请人：——

  公开号：US4705795A

  公开（公告）日：1987-11-10
• One pot rhodium catalysed three component dehydrogenation route to fused and spiro-heterocycles
  作者：Matthew Allison、Visuvanathar Sridharan

  DOI：10.1016/j.tetlet.2015.10.007

  日期：2015.11

  A three component rhodium-catalysed dehydrogenation reaction has been used for the synthesis of fused and spiro-heterocycles. The reaction proceeds in good yields with the formation of three new bonds and four stereocentres. Crown Copyright (C) 2015 Published by Elsevier Ltd. All rights reserved.