methyl 4-amino-5-methoxy-2-methylbenzoate | 1427436-95-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: methyl 4-amino-5-methoxy-2-methylbenzoate
• CAS: 1427436-95-0
• 化学式: C₁₀H₁₃NO₃
• 分子量: 195.218
• InChiKey: HACFSCLSBOOFTM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  61.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  methyl 4-amino-5-methoxy-2-methylbenzoate 在 tris-(dibenzylideneacetone)dipalladium(0) 、 lithium aluminium tetrahydride 、 caesium carbonate 、 pyridinium chlorochromate 、 4,5-双二苯基膦-9,9-二甲基氧杂蒽 作用下， 以 四氢呋喃 、 1,4-二氧六环 、 二氯甲烷 为溶剂， 反应 17.0h， 生成 4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-5-methoxy-2-methylbenzaldehyde
  参考文献：
  名称：

  [EN] BIFUNCTIONAL COMPOUNDS THAT DEGRADE ALK AND USES THEREOF
  [FR] COMPOSÉS BIFONCTIONNELS DÉGRADANT ALK ET LEURS UTILISATIONS

  摘要：

  Disclosed are bifunctional compounds (degraders) that target ALK for degradation. Also disclosed are pharmaceutical compositions containing the degraders and methods of using the bifunctional compounds to treat diseases and disorders characterized or mediated by aberrant ALK activity.

  公开号：

  WO2023278325A1
• 作为产物：
  描述：

  5-methoxy-2-methyl-4-nitrobenzonitrile 在 氯化亚砜 、 氨基甲酸 、 硫酸 、 溶剂黄146 、 锌 作用下， 以 甲醇 、 水 为溶剂， 反应 9.0h， 生成 methyl 4-amino-5-methoxy-2-methylbenzoate
  参考文献：
  名称：

  [EN] BIFUNCTIONAL COMPOUNDS THAT DEGRADE ALK AND USES THEREOF
  [FR] COMPOSÉS BIFONCTIONNELS DÉGRADANT ALK ET LEURS UTILISATIONS

  摘要：

  Disclosed are bifunctional compounds (degraders) that target ALK for degradation. Also disclosed are pharmaceutical compositions containing the degraders and methods of using the bifunctional compounds to treat diseases and disorders characterized or mediated by aberrant ALK activity.

  公开号：

  WO2023278325A1

文献信息

• [EN] INDOLE CARBOXAMIDE DERIVATIVES AS P2X7 RECEPTOR ANTAGONISTS<br/>[FR] DÉRIVÉS D'INDOLE CARBOXAMIDE UTILISÉS EN TANT QU'ANTAGONISTES DU RÉCEPTEUR P2X7
  申请人：ACTELION PHARMACEUTICALS LTD

  公开号：WO2014097140A1

  公开（公告）日：2014-06-26

  The invention relates to indole carboxamide derivatives of formula (I), wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10 and n are as defined in the description, their preparation and their use as pharmaceutically active compounds.

  这项发明涉及式(I)的吲哚羧酰胺衍生物，其中R1、R2、R3、R4、R5、R6、R7、R8、R9、R10和n如描述中所定义，它们的制备以及它们作为药用活性化合物的用途。
• [EN] FUNGICIDAL ARYL AMIDINES<br/>[FR] ARYLAMIDINES FONGICIDES
  申请人：DOW AGROSCIENCES LLC

  公开号：WO2020237131A1

  公开（公告）日：2020-11-26

  This disclosure relates to aryl amidines of Formula I and their use as fungicides. One embodiment of the present disclosure is a use of a compound of Formula I, for protection of a plant against attack by a phytopathogenic organism or the treatment of a plant infested by a phytopathogenic organism, comprising the application of a compound of Formula I, or a composition comprising the compound to soil, a plant, a part of a plant, foliage, and/or roots.

  本公开涉及公式I的芳基脒和其作为杀菌剂的用途。本公开的一个实施例是使用公式I的化合物，用于保护植物免受植物病原体的侵害或治疗被植物病原体侵害的植物，包括将公式I的化合物或含有该化合物的组合物施用到土壤、植物、植物部分、叶片和/或根部。
• [EN] FUNGICIDAL ARYL AMIDINES<br/>[FR] ARYLE AMIDINES FONGICIDES
  申请人：CORTEVA AGRISCIENCE LLC

  公开号：WO2022109362A1

  公开（公告）日：2022-05-27

  This disclosure relates to aryl amidines of Formula (I) and their use as fungicides.

  本公开涉及式(I)的芳基脒类化合物及其作为杀真菌剂的用途。
• INDOLE CARBOXAMIDE DERIVATIVES AS P2X7 RECEPTOR ANTAGONIST
  申请人：ACTELION PHARMACEUTICALS LTD

  公开号：US20150322008A1

  公开（公告）日：2015-11-12

  The invention relates to indole carboxamide derivatives of formula (I), wherein R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are as defined in the description, their preparation and their use as pharmaceutically active compounds.

  本发明涉及公式（I）中的吲哚羧酰胺衍生物，其中R1、R2、R3、R4、R5和R6如描述中所定义，其制备和用作药学活性化合物。
• INDOLE CARBOXAMIDE DERIVATIVES AS P2X7 RECEPTOR ANTAGONISTS
  申请人：ACTELION PHARMACEUTICALS LTD

  公开号：US20150344425A1

  公开（公告）日：2015-12-03

  The invention relates to indole carboxamide derivatives of formula (I), wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 and n are as defined in the description, their preparation and their use as pharmaceutically active compounds.

  该发明涉及式(I)的吲哚羧酰胺衍生物，其中R1、R2、R3、R4、R5、R6、R7、R8、R9、R10和n如描述中所定义，它们的制备以及它们作为药物活性化合物的用途。