methyl 5,8-dioxo-6,7,8,9-tetrahydro-1H-pyrido[2,3-b]azepine-6-carboxylate | 884196-24-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩并吡啶类
• 英文名称: methyl 5,8-dioxo-6,7,8,9-tetrahydro-1H-pyrido[2,3-b]azepine-6-carboxylate
• 英文别名: methyl 5,8-dioxo-7,9-dihydro-6H-pyrido[2,3-b]azepine-6-carboxylate
• CAS: 884196-24-1
• 化学式: C₁₁H₁₀N₂O₄
• 分子量: 234.211
• InChiKey: IFHLDROIUUZRHL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  85.4
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Lactam compounds useful as protein kinase inhibitors
  申请人：Blackburn Christopher

  公开号：US20060100194A1

  公开（公告）日：2006-05-11

  The present invention provides novel compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various diseases.

  本发明提供了一种新型化合物，可用作蛋白激酶抑制剂。本发明还提供了包含本发明化合物的制药组合物以及使用该组合物治疗各种疾病的方法。
• LACTAM COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS
  申请人：Blackburn Christopher

  公开号：US20120178739A1

  公开（公告）日：2012-07-12

  The present invention provides novel compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various diseases.

  本发明提供了一种新型化合物，可用作蛋白激酶抑制剂。本发明还提供了包含所述化合物的药物组合物，以及使用该组合物治疗各种疾病的方法。
• US7459448B2
  申请人：——

  公开号：US7459448B2

  公开（公告）日：2008-12-02
• US7935694B2
  申请人：——

  公开号：US7935694B2

  公开（公告）日：2011-05-03
• [EN] LACTAM COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS<br/>[FR] COMPOSES A BASE DE LACTAME UTILES EN TANT QU'INHIBITEURS DE LA PROTEINE KINASE
  申请人：MILLENNIUM PHARM INC

  公开号：WO2006041773A2

  公开（公告）日：2006-04-20

  The present invention provides novel compounds of formula (I) or a pharmaceutically acceptable salt thereof; wherein A, Re, Rb, Rc, Rd, G1, Y1, and Y2 have the meaning as given in the claims useful as inhibitors of protein kinases. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various diseases.