1,1-dibenzylethylamine hydrochloride | 936647-23-3

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: 1,1-dibenzylethylamine hydrochloride
• 英文别名: 1,1-Dibenzylethylamine hydrochloride；2-methyl-1,3-diphenylpropan-2-amine;hydrochloride
• CAS: 936647-23-3
• 化学式: C₁₆H₁₉N*ClH
• 分子量: 261.794
• InChiKey: BGXJDEAUEFTNIY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.52
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  27.6
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  乙腈 、 苄基氯化镁 在 titanium(IV) isopropylate 盐酸 作用下， 以 乙醚 、 二氯甲烷 为溶剂， 以40%的产率得到1,1-dibenzylethylamine hydrochloride
  参考文献：
  名称：

  Addition of organometallic reagents to nitriles promoted by titanium(IV) isopropoxide as a procedure of synthesis of primary tert-alkylamines

  摘要：

  Grignard reagents are able to add twice to nitriles in the presence of titanium(IV) isopropoxide providing primary tert-alkylamines in a fair yield. The conditions and structural features of reagents required for successful reaction were established. A possibility to apply two different organometallic reagents was demonstarated, in particular, the use of organolithium compounds in the second stage.

  DOI：

  10.1134/s1070428007100016

文献信息

• Addition of organometallic reagents to nitriles promoted by titanium(IV) isopropoxide as a procedure of synthesis of primary tert-alkylamines
  作者：O. A. Tomashenko、V. V. Sokolov、A. A. Tomashevskii、A. A. Potekhin、A. de Meijere

  DOI：10.1134/s1070428007100016

  日期：2007.10

  Grignard reagents are able to add twice to nitriles in the presence of titanium(IV) isopropoxide providing primary tert-alkylamines in a fair yield. The conditions and structural features of reagents required for successful reaction were established. A possibility to apply two different organometallic reagents was demonstarated, in particular, the use of organolithium compounds in the second stage.