6,6-Dimethyl-2-methoxycarbonyl-4,6-dihydrothieno<3,4-b>thiophene 5,5-dioxide | 144847-54-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩并噻吩类
• 英文名称: 6,6-Dimethyl-2-methoxycarbonyl-4,6-dihydrothieno<3,4-b>thiophene 5,5-dioxide
• CAS: 144847-54-1
• 化学式: C₁₀H₁₂O₄S₂
• 分子量: 260.335
• InChiKey: ZZNUTTHJIQHFMI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  16.0
• 可旋转键数：
  1.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  60.44
• 氢给体数：
  0.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  N-苯基马来酰亚胺 、 6,6-Dimethyl-2-methoxycarbonyl-4,6-dihydrothieno<3,4-b>thiophene 5,5-dioxide 以 环丁砜 为溶剂， 反应 3.0h， 以90%的产率得到Methyl 8,8-dimethyl-6-phenyl-4,4a,5,7,7a,8-hexahydrothieno<2,3-e>isoindole-5,7-dione-2-carboxylate
  参考文献：
  名称：

  杂环稠合的2,5-二氢噻吩S，S-二氧化物作为杂环邻喹啉甲烷的前体

  摘要：

  2,5-Dihydrothiophene 5,5-dioxides 8 and 6 have been obtained by interception of flash-pyrolytically produced 2,3-dihydro-2,3-bis(methylene)thiophene with sulfur dioxide and from methyl 4,5-bischloromethylthiophene-2-carboxylate by reaction with sodium sulfide and oxidation. Pyrazole fused analogues 15 and 16 (R = Me and COPh) were prepared from 3-phenylsulfonyl-2,5-dihydrothiophene S,S-dioxide by cycloaddition

  DOI：

  10.1016/s0040-4020(01)80480-4
• 作为产物：
  描述：

  2-Methoxycarbonyl-4,6-dihydrothieno<3,4-b>thiophene 5,5-dioxide 、 碘甲烷 在 lithium diisopropyl amide 作用下， 生成 6-Methyl-2-methoxycarbonyl-4,6-dihydrothieno<3,4-b>thiophene 5,5-dioxide 、 6,6-Dimethyl-2-methoxycarbonyl-4,6-dihydrothieno<3,4-b>thiophene 5,5-dioxide
  参考文献：
  名称：

  杂环稠合的2,5-二氢噻吩S，S-二氧化物作为杂环邻喹啉甲烷的前体

  摘要：

  2,5-Dihydrothiophene 5,5-dioxides 8 and 6 have been obtained by interception of flash-pyrolytically produced 2,3-dihydro-2,3-bis(methylene)thiophene with sulfur dioxide and from methyl 4,5-bischloromethylthiophene-2-carboxylate by reaction with sodium sulfide and oxidation. Pyrazole fused analogues 15 and 16 (R = Me and COPh) were prepared from 3-phenylsulfonyl-2,5-dihydrothiophene S,S-dioxide by cycloaddition

  DOI：

  10.1016/s0040-4020(01)80480-4

文献信息

• Heterocyclic fused 2,5-dihydrothiophene S,S-dioxides as precursors to heterocyclic o-quinodimethanes
  作者：Lynne M. Chaloner、Andrew P.A. Crew、Paul M. O'Neill、Richard C. Storr、Michael Yelland

  DOI：10.1016/s0040-4020(01)80480-4

  日期：1992.1

  5-bischloromethylthiophene-2-carboxylate by reaction with sodium sulfide and oxidation. Pyrazole fused analogues 15 and 16 (R = Me and COPh) were prepared from 3-phenylsulfonyl-2,5-dihydrothiophene S,S-dioxide by cycloaddition of diazomethane, base induced aromatisation and N-substitution of the sulfone 14. Reaction of 3-acetyl-4-phenylthio-2,5-dihydrothiophene S,S-dioxide with hydrazine and interception of

  2,5-Dihydrothiophene 5,5-dioxides 8 and 6 have been obtained by interception of flash-pyrolytically produced 2,3-dihydro-2,3-bis(methylene)thiophene with sulfur dioxide and from methyl 4,5-bischloromethylthiophene-2-carboxylate by reaction with sodium sulfide and oxidation. Pyrazole fused analogues 15 and 16 (R = Me and COPh) were prepared from 3-phenylsulfonyl-2,5-dihydrothiophene S,S-dioxide by cycloaddition