(6S,9aS)-8-(3-acetylbenzyl)-2-allyl-6-(4-hydroxy-benzyl)-4,7-dioxohexahydropyrazino[2,1-c][1,2,4]triazine-1-carboxylic acid benzylamide | 1145675-24-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (6S,9aS)-8-(3-acetylbenzyl)-2-allyl-6-(4-hydroxy-benzyl)-4,7-dioxohexahydropyrazino[2,1-c][1,2,4]triazine-1-carboxylic acid benzylamide
• 英文别名: (6S,9aS)-8-[(3-acetylphenyl)methyl]-N-benzyl-6-[(4-hydroxyphenyl)methyl]-4,7-dioxo-2-prop-2-enyl-3,6,9,9a-tetrahydropyrazino[2,1-c][1,2,4]triazine-1-carboxamide
• CAS: 1145675-24-6
• 化学式: C₃₃H₃₅N₅O₅
• 分子量: 581.671
• InChiKey: APGUWUYWMWWXNU-KYJUHHDHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  43
• 可旋转键数：
  9
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  114
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• NOVEL COMPOUNDS OF REVERSE TURN MIMETICS AND THE USE THEREOF
  申请人：Chung Jae Uk

  公开号：US20100286094A1

  公开（公告）日：2010-11-11

  Conformationally constrained compounds that are novel and mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins and having bicyclic framework are disclosed, as well as their prodrugs. Such reverse-turn mimetic structures and pro-drugs have utility over a wide range of fields, including use as diagnostic and therapeutic agents. The invention also relates to a use of such compounds for the preparation of a medicament for treating or preventing cancer including an acute myeloid leukemia.
• US7671054B1
  申请人：——

  公开号：US7671054B1

  公开（公告）日：2010-03-02
• US8049008B2
  申请人：——

  公开号：US8049008B2

  公开（公告）日：2011-11-01
• US8080657B2
  申请人：——

  公开号：US8080657B2

  公开（公告）日：2011-12-20
• US8138337B2
  申请人：——

  公开号：US8138337B2

  公开（公告）日：2012-03-20