4-氟苯甲烷磺酸 | 1064778-57-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 4-氟苯甲烷磺酸
• 英文名称: (4-fluorophenyl)methanesulfonic acid-d2
• 英文别名: (4-fluorophenyl)methanesulfonic acid
• CAS: 1064778-57-9
• 化学式: C₇H₇FO₃S
• mdl: MFCD14708220
• 分子量: 190.195
• InChiKey: ZJNWHALUTJHTAM-UHFFFAOYSA-N

物化性质

• 密度：
  1.480±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.142
• 拓扑面积：
  62.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-氟苯甲烷磺酸 在 氯化亚砜 、 hydrazine hydrate 、 N,N-二甲基甲酰胺 作用下， 以 二氯甲烷 、 二甲基亚砜 为溶剂， 反应 15.0h， 生成 4-肼基-N-甲基苯甲磺酰胺
  参考文献：
  名称：

  一种简便的对肼基苯磺酸化合物的制备方法

  摘要：

  本发明提供了一种对肼基苯磺酸化合物的制备方法，以对氟苄氯为起始原料，经过的磺酸化，酰氯化，缩合，取代等方法得到目标产物，该方法原料易得，操作简便，成本低，危险性低，该化合物在药物化学领域具有广泛的应用前景。

  公开号：

  CN110981760A
• 作为产物：
  描述：

  4-氟氯苄 在 sodium sulfite 作用下， 以 水 、 丙酮 为溶剂， 反应 12.0h， 以82%的产率得到4-氟苯甲烷磺酸
  参考文献：
  名称：

  一种简便的对肼基苯磺酸化合物的制备方法

  摘要：

  本发明提供了一种对肼基苯磺酸化合物的制备方法，以对氟苄氯为起始原料，经过的磺酸化，酰氯化，缩合，取代等方法得到目标产物，该方法原料易得，操作简便，成本低，危险性低，该化合物在药物化学领域具有广泛的应用前景。

  公开号：

  CN110981760A

文献信息

• PROCESS FOR PRODUCING AMINOALKYLSULFONIC ACID AND METHOD OF SALT EXCHANGE FOR SALT THEREOF
  申请人：Wako Pure Chemical Industries, Ltd.

  公开号：EP1548002A1

  公开（公告）日：2005-06-29

  The present invention relates to a method for efficiently producing an aminoalkylsulfonic acid in an industrial scale, and provides    "a process for producing an aminoalkylsulfonic acid represented by the general formula [2]:    wherein R1 and R2 are each independently a hydrogen atom, an alkyl group, an aryl group or an aralkyl group; and R3 and R4 are each independently a hydrogen atom or an alkyl group, comprising reacting an aminoalkylsulfonate salt represented by the general formula [1]:    wherein M is an alkali metal atom, an organic ammonium ion or an ammonium ion; and R1 to R4 are the same as described above,    an aqueous solution thereof, or a solution dissolving any one of them in a water-soluble organic solvent, selected from alcohols having 1 to 3 carbon atoms, carboxylic acids having 2 to 12 carbon atoms and dimethylformamide, with an organic acid; and    a method of salt exchange for an aminoalkylsulfonate salt represented by the general formula [1']:    wherein M' is an alkali metal atom, an organic ammonium ion or an ammonium ion; and R1 and R4 are the same as described above, comprising reacting an aminoalkylsulfonate salt represented by the above general formula [2] with a hydroxide represented by the general formula [6]:         M'OH     [6]    wherein M' is the same as described above, in an alcohol or water".

  本发明涉及一种在工业规模上高效生产氨基磺酸的方法，并提供“一种生产由通式[2]表示的氨基磺酸的方法：其中R1和R2分别是氢原子、烷基、芳基或芳基烷基；R3和R4分别是氢原子或烷基的氨基磺酸盐发生反应所得的方法，通式[1]表示如下：其中M是碱金属原子、有机铵离子或铵离子；R1至R4与上述相同，其水溶液或将任何一种溶解于水溶性有机溶剂中的溶液，所选的有1至3个碳原子的醇、有2至12个碳原子的羧酸和二甲基甲酰胺，与有机酸反应；以及氨基磺酸盐交换的方法，通式[1']表示如下：其中M'是碱金属原子、有机铵离子或铵离子；R1和R4与上述相同，包括将上述通式[2]表示的氨基磺酸盐与通式[6]表示的氢氧化物发生反应：M'OH [6]其中M'与上述相同，在醇或水中”。
• PROCESS FOR PRODUCING ESTER COMPOUND
  申请人：Imazeki Shigeaki

  公开号：US20100324314A1

  公开（公告）日：2010-12-23

  PROBLEM To provide an environmentally-friendly method for producing industrially an ester compound. SOLUTION The present invention is a method for producing an ester compound which comprises subjecting a carboxylic acid and an alcohol to dehydration-condensation reaction using an involatile acid catalyst and then removing the residual acid catalyst by bringing a weak basic substance into contact with the residual acid catalyst.

  问题提供一种生产工业酯化合物的环保方法。 解决方案是一种生产酯化合物的方法，包括将羧酸和醇经过脱水缩合反应，使用一种不挥发的酸催化剂，然后通过将弱碱性物质与残留的酸催化剂接触来去除残留的酸催化剂。
• Process for producing of an aminoalkylsulfonic acid and a method of salt exchange for a salt thereof
  申请人：Kimura Takuhiro

  公开号：US20050261370A1

  公开（公告）日：2005-11-24

  A process for producing an aminoalkylsulfonic acid of formula [2]: wherein R 1 and R 2 are each independently hydrogen, alkyl, aryl or aralkyl; and R 3 and R 4 are each independently hydrogen or alkyl, comprising reacting an aminoalkylsulfonate salt of formula [1]: wherein M is alkali metal, organic ammonium or ammonium ion; and R 1 to R 4 are as described above, an aqueous solution thereof, or a solution dissolving any one of them in a water-soluble organic solvent, selected from alcohols having 1 to 3 carbon, carboxylic acids having 2 to 12 carbon and dimethylformamide, with an organic acid; and a method of salt exchange for an aminoalkylsulfonate salt of formula [1′]: wherein M′ is alkali metal, organic ammonium or ammonium ion; and R 1 and R 4 are as described above, comprising reacting the aminoalkylsulfonate salt formula [2] with a hydroxide of formula [6]: M′OH  [6] wherein M′ is as described above, in alcohol or water.

  一种生产化学式[2]的氨基烷基磺酸的方法：其中R1和R2各自独立地表示氢、烷基、芳香基或芳基烷基；R3和R4各自独立地表示氢或烷基，包括反应化学式[1]的氨基烷基磺酸盐：其中M为碱金属、有机铵或铵离子；R1至R4如上所述，其水溶性有机溶剂中的水溶性溶液或溶解其中任何一种的溶液，所选的有机酸；以及化学式[1']的氨基烷基磺酸盐的盐交换方法：其中M'为碱金属、有机铵或铵离子；R1和R4如上所述，包括将氨基烷基磺酸盐化学式[2]与化学式[6]的氢氧化物反应：M'OH [6]，其中M'如上所述，在醇或水中。
• Hybrid onium salt
  申请人：Ishihara Masami

  公开号：US20050020710A1

  公开（公告）日：2005-01-27

  The present invention relates to a hybrid type onium salt having an iodonium salt and a sulfonium salt in the molecule, useful, for example, as a cationic type photopolymerization initiator and an acid generator for a chemically amplified resist and provides a hybrid type onium salt shown by the general formula [1]: [wherein R 1 to R 3 are each independently a halogen atom, an alkyl group, a haloalkyl group, an aryl group, an alkoxy group, an aryloxy group, an alkylthio group, an arylthio group or an amino group which maybe substituted; Q 1 is a direct-linkage, an oxygen atom, a sulfur atom or a lower alkylene chain; T 1 is an alkylene group or an arylene group, which may have a substituent selected from the group consisting of a halogen atom, an alkyl group, a haloalkyl group, an aryl group, an alkoxy group, an aryloxy group, an alkylthio group, an arylthio group and an amino group which may be substituted; and R 4 is an alkyl group, an alkenyl group, an aryl group or an aralkyl group, which may have a substituent selected from the group consisting of a halogen atom, an alkyl group, a haloalkyl group, an aryl group, an alkoxy group, an aryloxy group, an alkylthio group, an arylthio group and an amino group which may be substituted or a group shown by the general formula [2]: (wherein R 5 to R 7 are each independently a halogen atom, an alkyl group, a haloalkyl group, an aryl group, an alkoxy group, an aryloxy group, an alkylthio group, an arylthio group or an amino group which maybe substituted; Q 2 is a direct-linkage, an oxygen atom, a sulfur atom or a lower alkylene chain; T 2 an alkylene group or an arylene group, which may have a substituent selected from the group consisting of a halogen atom, an alkyl group, a haloalkyl group, an aryl group, an alkoxy group, an aryloxy group, an alkylthio group, an arylthio group and an amino group which may be substituted; A 3 is a counter anion; m is an integer of 0 to 4; and two ns are each independently an integer of 0 to 5); A 1 and A 2 are each independently a counter anion; and m and n are the same as described above], and a polymerization initiator or an acid generator, comprising said onium salt.

  本发明涉及一种杂化型离子盐，其分子中具有碘化离子盐和亚砜盐，例如，作为阳离子型光聚合引发剂和化学放大型抗蚀剂的酸发生剂有用，并提供由通式[1]所示的杂化型离子盐：[其中R1至R3分别独立地是卤素原子、烷基、卤代烷基、芳基、烷氧基、芳氧基、烷硫基、芳硫基或氨基，可被取代；Q1是直链、氧原子、硫原子或较低的烷基链；T1是烷基或芳基，可具有从卤素原子、烷基、卤代烷基、芳基、烷氧基、芳氧基、烷硫基、芳硫基和可被取代的氨基中选择的取代基；R4是烷基、烯丙基、芳基或芳基烷基，可具有从卤素原子、烷基、卤代烷基、芳基、烷氧基、芳氧基、烷硫基、芳硫基和可被取代的氨基中选择的取代基或由通式[2]所示的基：（其中R5至R7分别独立地是卤素原子、烷基、卤代烷基、芳基、烷氧基、芳氧基、烷硫基、芳硫基或氨基，可被取代；Q2是直链、氧原子、硫原子或较低的烷基链；T2是烷基或芳基，可具有从卤素原子、烷基、卤代烷基、芳基、烷氧基、芳氧基、烷硫基、芳硫基和可被取代的氨基中选择的取代基；A3是一个对离子；m是0到4的整数；两个n各自独立地是0到5的整数）；A1和A2各自独立地是一个对离子；m和n与上述描述相同]，以及包含该离子盐的聚合引发剂或酸发生剂。
• Heterocycle-bearing onium salts
  申请人：Ishihara Masami

  公开号：US20050233253A1

  公开（公告）日：2005-10-20

  The present invention relates to a heterocycle-containing onium salt useful as, for example, a cationic photopolymerization initiator and an acid generator for a chemically amplified resist, and provides “a heterocycle-containing onium salt shown by the general formula [1]: [wherein R is a group shown by the general formula [2]: (wherein R 3 and R 4 are each independently a halogen atom, an alkyl group which may have a halogen atom or an aryl group as a substituent, or an aryl group which may have a halogen atom or a lower alkyl group as a substituent; X 2 is an oxygen atom or a sulfur atom; i is an integer of 0 to 4; and j is an integer of 0 to 3), or a group shown by the general formula [3]: (wherein R 5 and R 6 are each independently a halogen atom, an alkyl group which may have a halogen atom or an aryl group as a substituent, or an aryl group which may have a halogen atom or a lower alkyl group as a substituent; X 3 and X 4 are each independently an oxygen atom or a sulfur atom; p is an integer of 0 to 2; and q is an integer of 0 to 3); R 1 and R 2 are each independently a halogen atom, an alkyl group which may have a halogen atom or an aryl group as a substituent, or an aryl group which may have a halogen atom or a lower alkyl group as a substituent; m and n are each independently an integer of 0 to 5; and A is a halogen atom or an anion derived from an inorganic strong acid, an organic acid or a compound shown by the general formula [4]: HM 1 (R 7 ) 4 [4] (wherein M 1 is a boron atom or a gallium atom; and R 7 is an aryl group which may have a substituent selected from a lower haloalkyl group, a halogen atom, a nitro group and a cyano group)]” or “a heterocycle-containing onium salt shown by the general formula [35]: [wherein R 26 and R 27 are each independently an aryl group which may have a halogen atom or a lower alkyl group as a substituent, a group shown by the above-mentioned general formula [2], or a group shown by the above-mentioned general formula [3]; and A 3 is a halogen atom or an anion derived from an inorganic strong acid, an organic acid or a compound shown by the general formula [4]; and provided that at least one of R 26 and R 27 is a group shown by the above-mentioned general formula [2] or [3], and when only one of R 26 and R 27 is a group shown by the above-mentioned general formula [2] or [3], A 3 is an anion derived from an inorganic strong acid shown by the general formula [36]; HM 3 F 6 [36] (wherein M 3 is a phosphorus atom, an arsenic atom or an antimony atom), an organic acid or a compound shown by the general formula [4]]”.

  本发明涉及一种含杂环离子盐，例如，用作阳离子光聚合引发剂和化学增感抗蚀剂的酸发生剂，并提供“一种由通式[1]所示的含杂环离子盐：[其中R是由通式[2]所示的基团：（其中R3和R4分别独立地是卤素原子，可能具有卤素原子或芳基取代基的烷基基团，或可能具有卤素原子或较低烷基基团的芳基基团；X2是氧原子或硫原子；i是0到4的整数；j是0到3的整数），或由通式[3]所示的基团：（其中R5和R6分别独立地是卤素原子，可能具有卤素原子或芳基取代基的烷基基团，或可能具有卤素原子或较低烷基基团的芳基基团；X3和X4分别独立地是氧原子或硫原子；p是0到2的整数；q是0到3的整数）；R1和R2分别独立地是卤素原子，可能具有卤素原子或芳基取代基的烷基基团，或可能具有卤素原子或较低烷基基团的芳基基团；m和n分别独立地是0到5的整数；A是从无机强酸，有机酸或由通式[4]所示的化合物得到的卤素离子或阴离子：HM1（R7）4[4]（其中M1是硼原子或镓原子；R7是可能选择自较低卤代烷基基团、卤素原子、硝基基团和氰基团的芳基基团）]”或“一种由通式[35]所示的含杂环离子盐：[其中R26和R27分别独立地是可能具有卤素原子或较低烷基基团的芳基基团，上述通式[2]所示的基团或上述通式[3]所示的基团；A3是从无机强酸，有机酸或由通式[4]所示的化合物得到的卤素离子或阴离子；并且至少其中之一的R26和R27是上述通式[2]或[3]所示的基团，当仅R26和R27中的一个是上述通式[2]或[3]所示的基团时，A3是从通式[36]所示的无机强酸得到的阴离子：HM3F6[36]（其中M3是磷原子、砷原子或锑原子），有机酸或由通式[4]所示的化合物]”。