N-(N'-tritylaminobutyl)-α-D-mannopyranosylamine | 1092791-62-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: N-(N'-tritylaminobutyl)-α-D-mannopyranosylamine
• 英文别名: (2R,3S,4S,5S,6S)-2-(hydroxymethyl)-6-[4-(tritylamino)butylamino]oxane-3,4,5-triol
• CAS: 1092791-62-2
• 化学式: C₂₉H₃₆N₂O₅
• 分子量: 492.615
• InChiKey: KLYVSWROHBLVDA-MASCHLQQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  36
• 可旋转键数：
  11
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  114
• 氢给体数：
  6
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  D-甘露糖 、 N1-Triphenylmethyl-1,4-diaminobutane 以 甲醇 为溶剂， 生成 N-(N'-tritylaminobutyl)-α-D-mannopyranosylamine
  参考文献：
  名称：

  Trityl-derivatized carbohydrates immobilized on a polystyrene microplate

  摘要：

  Carbohydrate biosensors, including carbohydrate arrays, are attracting increased attention for the comprehensive and high-throughput investigation of protein-carhohydrate interactions. Here, we describe an effective approach to fabricating a robust microplate-based carbohydrate array capable of probing protein binding and screening for inhibitors in a high-throughout manner. This approach involves the derivatization of carbohydrates with a trityl group through an alkyl linker and the immobilization of the trityl-derivatized carbohydrates (mannose and maltose) onto microplates noncovalently to construct carbohydrate arrays. The trityl carbohydrate derivative has very good immobilization efficiency for polystyrene microplates and strong resistance to aqueous washing. The carbohydrate arrays can probe the interactions with the lectin Concanavalin A and screen this protein for the well-known inhibitors methyl alpha-D-mannopyramoside and methyl alpha-D-glucopyranoside in a high-throughput manner. The method described in this paper represents a convenient way of fabricating robust noncovalent carbohydrate arrays on microplates and offers a convenient platform for high-throughput drug screening. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.carres.2008.08.021