7-benzoyl-3-phenyl-N-(1,3,3-trimethylbicyclo[2.2.1]heptan-2-yl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide | 1094086-54-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 7-benzoyl-3-phenyl-N-(1,3,3-trimethylbicyclo[2.2.1]heptan-2-yl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide
• 英文别名: 7-benzoyl-3-phenyl-N-(1,3,3-trimethyl-2-bicyclo[2.2.1]heptanyl)-6,8-dihydro-5H-imidazo[1,5-a]pyrazine-1-carboxamide
• CAS: 1094086-54-0
• 化学式: C₃₀H₃₄N₄O₂
• 分子量: 482.626
• InChiKey: CIZPIBRUWICKSY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  36
• 可旋转键数：
  4
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  67.2
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• SUBSTITUTED IMIDAZOHETEROCYCLES
  申请人：Beckett R. Paul

  公开号：US20080318935A1

  公开（公告）日：2008-12-25

  The present invention provides substituted imidazoheterocyclic compounds having the structure of formula I Also provided are pharmaceutically acceptable salts, acid salts, hydrates, solvates and stereoisomers of the compounds of formula I. The compounds are useful as modulators of cannabinoid receptors and for the prophylaxis and treatment of cannabinoid receptor-associated diseases and conditions, such as pain, inflammation and pruritis.

  本发明提供了具有式I结构的取代咪唑杂环化合物。还提供了式I化合物的药用可接受盐、酸盐、水合物、溶剂合物和立体异构体。这些化合物可用作大麻素受体调节剂，用于预防和治疗与大麻素受体相关的疾病和症状，如疼痛、炎症和瘙痒。
• USES OF SUBSTITUTED IMIDAZOHETEROCYCLES
  申请人：Beckett R. Paul

  公开号：US20110034443A1

  公开（公告）日：2011-02-10

  The present invention provides methods of prevention and treatment of cannabinoid receptor-associated diseases and conditions, wherein the method includes administering a substituted imidazoheterocyclic compounds having the structure of formula I or a pharmaceutically acceptable salt, acid salt, hydrate, solvate or stereoisomer of a compound having the structure of formula I. The cannabinoid receptor-associated diseases and conditions preventable or treatable by the methods of the present invention include pain, inflammation and pruritis.

  本发明提供了预防和治疗与大麻素受体相关的疾病和症状的方法，其中该方法包括给予具有I式结构的取代咪唑杂环化合物或其药学上可接受的盐、酸盐、水合物、溶剂物或立体异构体。本发明的方法可预防或治疗与大麻素受体相关的疾病和症状，包括疼痛、炎症和瘙痒。
• US7517874B2
  申请人：——

  公开号：US7517874B2

  公开（公告）日：2009-04-14
• US8431565B2
  申请人：——

  公开号：US8431565B2

  公开（公告）日：2013-04-30
• US8859538B2
  申请人：——

  公开号：US8859538B2

  公开（公告）日：2014-10-14