4-(4-methoxyphenyl)-5-methyl-2-(3-nitrophenyl)-1H-imidazole | 1449522-81-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-(4-methoxyphenyl)-5-methyl-2-(3-nitrophenyl)-1H-imidazole
• CAS: 1449522-81-9
• 化学式: C₁₇H₁₅N₃O₃
• 分子量: 309.324
• InChiKey: ZUHUBEKBLJHRAI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  83.7
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  1-(对甲氧基苯基)2-硝基丙烯 、 3-硝基苯甲脒 盐酸盐 在 indium(III) oxide 、 potassium carbonate 作用下， 以 乙醇 为溶剂， 反应 6.0h， 以82%的产率得到4-(4-methoxyphenyl)-5-methyl-2-(3-nitrophenyl)-1H-imidazole
  参考文献：
  名称：

  Nano indium oxide catalyzed tandem cyclization of amidine with nitroolefin

  摘要：

  A tandem cyclization of amidine with nitroolefin has been described using nano In2O3 as an efficient catalyst. The reaction is effective for the preparation of 4,5-unsymmetrically substituted 1-H imidazole in moderate to good yields. The catalyst was successfully reused for four consecutive cycles with similar catalytic activities. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2013.07.050

文献信息

• Nano indium oxide catalyzed tandem cyclization of amidine with nitroolefin
  作者：Shubhanjan Mitra、Avik Kumar Bagdi、Adinath Majee、Alakananda Hajra

  DOI：10.1016/j.tetlet.2013.07.050

  日期：2013.9

  A tandem cyclization of amidine with nitroolefin has been described using nano In2O3 as an efficient catalyst. The reaction is effective for the preparation of 4,5-unsymmetrically substituted 1-H imidazole in moderate to good yields. The catalyst was successfully reused for four consecutive cycles with similar catalytic activities. (C) 2013 Elsevier Ltd. All rights reserved.