1-(3,6-dimethoxy-9H-carbazol-9-yl)ethanone | 1354900-08-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 1-(3,6-dimethoxy-9H-carbazol-9-yl)ethanone
• 英文别名: 1-(3,6-Dimethoxycarbazol-9-yl)ethanone；1-(3,6-dimethoxycarbazol-9-yl)ethanone
• CAS: 1354900-08-5
• 化学式: C₁₆H₁₅NO₃
• 分子量: 269.3
• InChiKey: IGTNQAKONSITBE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  40.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  N,N-bis(4-methoxyphenyl)acetamide 在 palladium diacetate 、 溶剂黄146 、 silver(l) oxide 作用下， 以76%的产率得到1-(3,6-dimethoxy-9H-carbazol-9-yl)ethanone
  参考文献：
  名称：

  Pd(II)-catalyzed intramolecular C–H activation/C–C cross coupling for the synthesis of carbazoles from diaryl acetamides

  摘要：

  Pd(II)-catalyzed intramolecular C-H activation/C-C cross coupling within N,N-diphenyl-acetamides allows the efficient formation of differently substituted carbazoles. In this cross-dehydrogenative coupling, many different functional groups are tolerated and the starting material N,N-diphenyl-acetamides can be easily prepared in one step from commercially available acetanilides and iodobenzenes. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.11.082

文献信息

• Pd(II)-catalyzed intramolecular C–H activation/C–C cross coupling for the synthesis of carbazoles from diaryl acetamides
  作者：Sichang Wang、Hui Mao、Zhangqin Ni、Yuanjiang Pan

  DOI：10.1016/j.tetlet.2011.11.082

  日期：2012.2

  Pd(II)-catalyzed intramolecular C-H activation/C-C cross coupling within N,N-diphenyl-acetamides allows the efficient formation of differently substituted carbazoles. In this cross-dehydrogenative coupling, many different functional groups are tolerated and the starting material N,N-diphenyl-acetamides can be easily prepared in one step from commercially available acetanilides and iodobenzenes. (C) 2011 Elsevier Ltd. All rights reserved.