2-Isocyano-5-methoxypyridine | 1270130-88-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-Isocyano-5-methoxypyridine
• CAS: 1270130-88-5
• 化学式: C₇H₆N₂O
• 分子量: 134.137
• InChiKey: GYINGKYPFHCDPO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  26.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-Isocyano-5-methoxypyridine 以 1,4-二氧六环 为溶剂， 以77%的产率得到2,8-dimethoxypyrido[2'',1'':2',3']imidazo[4',5':4,5]imidazo[1,2-a]pyridine
  参考文献：
  名称：

  Dimerization of 2-pyridylisonitriles produces π-extended fused heteroarenes useful as highly selective colorimetric and optical probes for copper ion

  摘要：

  A very simple synthesis of pyrido[2 '',1 '':2',3']imidazo[4',5':4,5]imidazo[1,2-a]Pyridines 2 was achieved from the dimerization of 2-pyridylisonitriles. The optical responses of these pi-extended fused heteroarenes to a series of metal ions were investigated by means of UV-visible absorption spectrum in acetonitrile. It was found that most of compounds 2 selectively responded to Cu2+, and the limit of detection was about 3.5 x 10(-7) M when using the best probe, 3,9-dimethylpyrido[2",1":2',3']imidazo[4',5':4,5] imidazol1,2-a]pyridine 2d. Meanwhile some compounds 2 specifically showed a color change from colorless to red or yellow when they are exposed to copper ion in acetonitrile, whereas other transitional, alkali and alkaline earth metal ions could not induce a color change. This work not only established a direct access to pi-extended fused heteroarenes, but also supplied novel sensitive and selective colorimetric and optical probes for copper ion. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2010.06.096