1-O-octadecyl-2-(11-oxo-(5Z,9Z,12E,14E)-prostatetraenoyl)-sn-glycero-3-phospho-(S)-glycerol | 1242246-23-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子
• 英文名称: 1-O-octadecyl-2-(11-oxo-(5Z,9Z,12E,14E)-prostatetraenoyl)-sn-glycero-3-phospho-(S)-glycerol
• CAS: 1242246-23-6
• 化学式: C₄₄H₇₆O₁₀P*Na
• 分子量: 819.045
• InChiKey: GGQXYMVBGQFOHP-QWAMVJGWSA-M

反应信息

• 作为产物：
  描述：

  在 氢氟酸 、 水 、 甲氧基三甲基硅烷 、 碳酸氢钠 作用下， 以 二氯甲烷 、 乙腈 、 水 为溶剂， 以4 mg的产率得到1-O-octadecyl-2-(11-oxo-(5Z,9Z,12E,14E)-prostatetraenoyl)-sn-glycero-3-phospho-(S)-glycerol
  参考文献：
  名称：

  Prostaglandin phospholipid conjugates with unusual biophysical and cytotoxic properties

  摘要：

  The synthesis of two secretory phospholipase A(2) IIA sensitive 15-deoxy-Delta(12,14)-prostaglandin J(2) phospholipid conjugates is described and their biophysical and biological properties are reported. The conjugates spontaneously form particles in the liposome size region upon dispersion in an aqueous buffer and both phospholipids are hydrolyzed by phospholipase A(2), but with different conversion rates and extent of hydrolysis. The cytotoxicity was evaluated in HT-29 and Colo205 cells and the conjugates induced cell death in the presence of phospholipase A(2) and surprisingly also in the absence of the enzyme. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.06.054