1-(2,4-Dichloro-phenyl)-6-methyl-1,4-dihydro-indeno[1,2-c]pyrazole-3-carbonyl chloride | 923036-60-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1-(2,4-Dichloro-phenyl)-6-methyl-1,4-dihydro-indeno[1,2-c]pyrazole-3-carbonyl chloride
• CAS: 923036-60-6
• 化学式: C₁₈H₁₁Cl₃N₂O
• 分子量: 377.657
• InChiKey: MIYPDLVKSIRGAK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.44
• 重原子数：
  24.0
• 可旋转键数：
  2.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  34.89
• 氢给体数：
  0.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  N-氨基哌啶盐酸盐 、 1-(2,4-Dichloro-phenyl)-6-methyl-1,4-dihydro-indeno[1,2-c]pyrazole-3-carbonyl chloride 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 5.0h， 以1.2 g的产率得到gp1a
  参考文献：
  名称：

  Tricyclic Pyrazoles. Part 1: Synthesis and Biological Evaluation of Novel 1,4-Dihydroindeno[1,2-c]pyrazol-based Ligands for CB1and CB2 Cannabinoid Receptors

  摘要：

  Cannabinoids receptors, cellular elements of the endocannabinoid system, have been the focus of extensive studies because of their potential functional role in several important physiological and pathological processes. To further evaluate the properties of CB receptors, especially CB1 and CB2 subtypes, we have designed, using SR141716A as a benchmark, a new series of rigid 1-aryl-1,4-dihydroindeno[1,2-c]pyrazole-3-carboxamides. Compounds I were synthesized from substituted 1-aryl-1,4-dihydroindeno[1,2-c]pyrazole-3-carboxylic acids and requisite amines. The various analogues were assayed for binding both to the brain and peripheral cannabinoid receptors (CB1 and CB2). Seven of the new compounds displayed very high in vitro CB2 binding affinities, especially 1a, 1b, 1c, 1e, 1g, 1h and 1j which showed K-i values of 0.34, 0.225, 0.27, 0.23, 0.385, 0.037 and 0.9 nM, respectively. Compounds 1a, 1b, 1c and 1h showed the highest selectivity for CB2 receptor with K-i(CB1) to K-i(CB2) ratios of 6029, 5635, 5814 and 9810, respectively. Noticeably, 1h exhibited the highest affinity and selectivity for CB2 receptors. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(02)00319-x
• 作为产物：
  描述：

  5-甲基-1-茚酮 在 氢氧化钾 、 氯化亚砜 、 sodium 作用下， 以 甲醇 、 乙醇 、 甲苯 为溶剂， 反应 8.0h， 生成 1-(2,4-Dichloro-phenyl)-6-methyl-1,4-dihydro-indeno[1,2-c]pyrazole-3-carbonyl chloride
  参考文献：
  名称：

  Tricyclic Pyrazoles. Part 1: Synthesis and Biological Evaluation of Novel 1,4-Dihydroindeno[1,2-c]pyrazol-based Ligands for CB1and CB2 Cannabinoid Receptors

  摘要：

  Cannabinoids receptors, cellular elements of the endocannabinoid system, have been the focus of extensive studies because of their potential functional role in several important physiological and pathological processes. To further evaluate the properties of CB receptors, especially CB1 and CB2 subtypes, we have designed, using SR141716A as a benchmark, a new series of rigid 1-aryl-1,4-dihydroindeno[1,2-c]pyrazole-3-carboxamides. Compounds I were synthesized from substituted 1-aryl-1,4-dihydroindeno[1,2-c]pyrazole-3-carboxylic acids and requisite amines. The various analogues were assayed for binding both to the brain and peripheral cannabinoid receptors (CB1 and CB2). Seven of the new compounds displayed very high in vitro CB2 binding affinities, especially 1a, 1b, 1c, 1e, 1g, 1h and 1j which showed K-i values of 0.34, 0.225, 0.27, 0.23, 0.385, 0.037 and 0.9 nM, respectively. Compounds 1a, 1b, 1c and 1h showed the highest selectivity for CB2 receptor with K-i(CB1) to K-i(CB2) ratios of 6029, 5635, 5814 and 9810, respectively. Noticeably, 1h exhibited the highest affinity and selectivity for CB2 receptors. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(02)00319-x

文献信息

• Tricyclic Pyrazoles. 4. Synthesis and Biological Evaluation of Analogues of the Robust and Selective CB₂ Cannabinoid Ligand 1-(2‘,4‘-Dichlorophenyl)-6-methyl-<i>N</i>-piperidin-1-yl- 1,4-dihydroindeno[1,2-<i>c</i>]pyrazole-3-carboxamide
  作者：Gabriele Murineddu、Paolo Lazzari、Stefania Ruiu、Angela Sanna、Giovanni Loriga、Ilaria Manca、Matteo Falzoi、Christian Dessì、Maria M. Curzu、Giorgio Chelucci、Luca Pani、Gérard A. Pinna

  DOI：10.1021/jm060920d

  日期：2006.12.1

  New analogues (2a-p) of the previously reported CB2 ligands 6-methyl- and 6-chloro-1-(2',4'-dichlorophenyl)-N-piperidin-1-yl-1,4-dihydroindeno[1,2-c]pyrazole-3-carboxamides (1a,b) have been synthesized and evaluated for cannabinoid receptor affinity. One example, 1-(2',4'-dichlorophenyl)-6-methyl-N-cyclohexyilamine-1,4-dihydroindeno[1,2-c]pyrazole-3-carboxamide (2a) was shown to have single digit nanomolar affinity for cannabinoid CB2 receptors. Furthermore, compounds 2a and 2b, as well as lead structures 1a, b, were also shown to be agonist in an in vitro model based on human promyelocytic leukemia HL-60 cells.