cis-1-cyclohexyl-2-phenyl-3-(p-toluyl)aziridine | 6372-29-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: cis-1-cyclohexyl-2-phenyl-3-(p-toluyl)aziridine
• 英文别名: (1-cyclohexyl-3c-phenyl-aziridin-2r-yl)-p-tolyl-methanone；(1-cyclohexyl-3c-phenyl-aziridin-2r-yl)-p-tolyl ketone；(1-Cyclohexyl-3c-phenyl-aziridin-2r-yl)-p-tolyl-keton；cis-1-Cyclohexyl-2-phenyl-3-p-tolyl-aziridin；[(2S,3S)-1-cyclohexyl-3-phenylaziridin-2-yl]-(4-methylphenyl)methanone
• CAS: 6372-29-8；6476-39-7；52599-14-1；106225-40-5；106225-41-6
• 化学式: C₂₂H₂₅NO
• 分子量: 319.447
• InChiKey: ABWDYIPGRJQNNT-MMBKUXRPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  20.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  cis-1-cyclohexyl-2-phenyl-3-(p-toluyl)aziridine 在 poly phosphoric acid ethyl ester hydrolysate 、 三氟化硼乙醚 作用下， 以 氯仿 为溶剂， 生成 1-Cyclohexyl-6-phenyl-2-(toluene-4-sulfonyl)-4-p-tolyl-1,2,5,6-tetrahydro-[1,2,3]triazine
  参考文献：
  名称：

  Novel Rearrangement of cis-N-Alkyl-3-phenylaziridin-2-yl Phenyl Ketone Tosylhydrazones with Ethlyl Ether-Boron Trifluoride. Preparation of 1,2,5,6-Tetrahydro-1,2,3-triazine Derivatives

  摘要：

  1-Alkyl-4,6-diphenyl-1,2,5,6-tetrahydro-2-tosyl-1,2, 3-triazine derivatives (8a-g,i-k) which had a new skeletal ring were obtained in moderate yield (77-49 %) by the rearrangement of cis-N-alkyl-3-phenylaziridin-2-yl phenyl ketone toslhydrazones (3a-g, i-k) with ethyl ether-boron trifluoride(1/1) (7) in chloroform under room temperature. The starting materials (3a-1) were prepared in good yield (88-39%) by the condensation of cis-N-alkyl-3-phenylaziridin-2-yl phenyl ketones (1a-1) with tosylhydrazine (2) in chloroform in the presence of PPE (polyphosphoric acid ethyl ester) hydrolysate as a catalyst.

  DOI：

  10.3987/com-95-7239
• 作为产物：
  描述：

  环己胺 、 2,3-Dibromo-3-phenyl-1-p-tolyl-propan-1-one 在 苯 作用下， 生成 cis-1-cyclohexyl-2-phenyl-3-(p-toluyl)aziridine 、 trans-1-cyclohexyl-2-phenyl-3-(p-toluyl)aziridine
  参考文献：
  名称：

  Ethylene Imine Ketones. VII.¹ Stereochemical Configurations, Absorption Spectra and Reactions with Phenylhydrazine²

  摘要：

  DOI：

  10.1021/ja01147a048

文献信息

• The addition of azomethine ylids to diphenylcyclopropenone: synthesis of novel 4-oxazolines
  作者：J. W. Lown、R. K. Smalley、G. Dallas

  DOI：10.1039/c19680001543

  日期：——
• Murthy, K. S. Keshava; Dhar, D. N., Journal of Heterocyclic Chemistry, 1984, vol. 21, p. 1699 - 1704
  作者：Murthy, K. S. Keshava、Dhar, D. N.

  DOI：——

  日期：——
• Ethylene Imine Ketones. VIII.¹ Stereochemical Configurations and Reactions with Organometallic Compounds²
  作者：Norman H. Cromwell、J. Hill Anglin、Frank W. Olsen、Norval G. Barker

  DOI：10.1021/ja01150a110

  日期：1951.6