| 1233132-50-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• CAS: 1233132-50-7
• 化学式: C₂₈H₂₈N₂O₂
• 分子量: 424.543
• InChiKey: HXDMTWBQNVNEJQ-ZGTJORTRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.84
• 重原子数：
  32.0
• 可旋转键数：
  8.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  47.62
• 氢给体数：
  0.0
• 氢受体数：
  4.0

反应信息

• 作为产物：
  描述：

  (S)-(-)- α-甲基苄胺 、 1-{4-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-phenyl}-ethanone 在 titanium(IV) isopropylate 作用下， 以 甲苯 为溶剂， 反应 23.0h， 生成 、
  参考文献：
  名称：

  Highly Diastereoselective Hydrogenation of Imines by a Bimetallic Pd−Cu Heterogeneous Catalyst

  摘要：

  An efficient and practical heterogeneous bimetallic Pd-Cu/C catalyst was identified as an alternative to Raney nickel for the highly diastereoselective hydrogenation of imines prepared from prochiral ketones and alpha-phenylethylamines. Chiral amines were obtained with diastereomeric excess (de) up to 94% using Pd-Cu/C, while conventional Pd-C catalysts afforded only 72% de. Optimization showed that a robust process required a palladium/copper ratio of 4:1. Evidence for the influence of catalyst pretreatment which may change the structure of the catalyst and/or metal oxidation states on the selectivity of the reaction is discussed. The bimetallic catalyst system provided consistent results on scale and performed reliably on a variety of substrates.

  DOI：

  10.1021/op1001325