| 1253283-90-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• CAS: 1253283-90-7
• 化学式: C₄₄H₅₆Cl₃NO₁₄Si
• 分子量: 957.371
• InChiKey: BJQXFIMQAOXSGP-FKBJHMNASA-N

反应信息

• 作为反应物：
  描述：

  (22S,25R)-3β,26-bis(tert-butyldimethylsilyloxy)-16,22-dihydroxycholest-5-ene 、 在 三氟甲磺酸三甲基硅酯 作用下， 以 二氯甲烷 为溶剂， 反应 3.0h， 以42%的产率得到
  参考文献：
  名称：

  Synthesis of cholestane glycosides bearing OSW-1 disaccharide or its 1→4-linked analogue and their antitumor activities

  摘要：

  For further structure-activity relationship (SAR) research of OSW saponins, a cholestane glycoside, namely 3 beta, 16 beta, 26-trihydroxycholest-5-en-22-one 16-O-(2-O-4-methoxybenzoyl-beta-D-xylopyranosyl)-(1 -> 3)-2-O- acetyl-alpha-L-arabinopyranoside (1) together with two 1 -> 4-linked disaccharide analogues (2 and 3) were synthesized. Their cytotoxic activities were evaluated by the standard MTT assay. Compound 1 showed potent cytotoxicity against five types of human tumor cells, with IC50 ranging between 1.3 and 73 nM. (c) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.07.085
• 作为产物：
  描述：

  、 三氯乙腈 在 1,8-二氮杂双环[5.4.0]十一碳-7-烯 作用下， 以 二氯甲烷 为溶剂， 反应 10.0h， 生成
  参考文献：
  名称：

  Synthesis of cholestane glycosides bearing OSW-1 disaccharide or its 1→4-linked analogue and their antitumor activities

  摘要：

  For further structure-activity relationship (SAR) research of OSW saponins, a cholestane glycoside, namely 3 beta, 16 beta, 26-trihydroxycholest-5-en-22-one 16-O-(2-O-4-methoxybenzoyl-beta-D-xylopyranosyl)-(1 -> 3)-2-O- acetyl-alpha-L-arabinopyranoside (1) together with two 1 -> 4-linked disaccharide analogues (2 and 3) were synthesized. Their cytotoxic activities were evaluated by the standard MTT assay. Compound 1 showed potent cytotoxicity against five types of human tumor cells, with IC50 ranging between 1.3 and 73 nM. (c) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.07.085