(1S,7aS)-1-Hydroxy-7a-methyl-5-oxo-2,3,5,6,7,7a-hexahydro-1H-indene-4-carboxylic acid | 31944-53-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (1S,7aS)-1-Hydroxy-7a-methyl-5-oxo-2,3,5,6,7,7a-hexahydro-1H-indene-4-carboxylic acid
• 英文别名: (1S,7aS)-1-hydroxy-7a-methyl-5-oxo-2,3,6,7-tetrahydro-1H-indene-4-carboxylic acid
• CAS: 31944-53-3
• 化学式: C₁₁H₁₄O₄
• 分子量: 210.23
• InChiKey: USCALRFWGZWWMZ-KWQFWETISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  74.6
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• CORTISTATIN ANALOGUES AND SYNTHESES THEROF
  申请人：President and Fellows of Harvard College

  公开号：US20150111921A1

  公开（公告）日：2015-04-23

  The present invention relates to analogs of cortistatin A, J, K, and L, having the general formula: I and salts thereof, wherein R 1 , R 2 , R 3 , R 4 , n, and m are as defined herein; processes for preparing such compounds and intermediates thereto; pharmaceutical compositions comprising such compounds; methods for treating a proliferative disease; methods for treating a disease associated with aberrant angiogenesis; methods for inhibiting angiogenesis; and processes for preparing cortistatin A, J, K, and L, and analogs thereof.
• CORTISTATIN ANALOGUES AND SYNTHESES THEREOF
  申请人：President and Fellows of Harvard College

  公开号：US20150376201A1

  公开（公告）日：2015-12-31

  The present invention relates to analogs of cortistatin A, J, K, and L, having the general formula: and salts thereof, wherein R 1 , R 2 , R 3 , R 4 , n, and m are as defined herein; processes for preparing such compounds and intermediates thereto; pharmaceutical compositions comprising such compounds; methods for treating a proliferative disease; methods for treating a disease associated with aberrant angiogenesis; methods for inhibiting angiogenesis; and processes for preparing cortistatin A, J, K, and L, and analogs thereof.
• US4052447A
  申请人：——

  公开号：US4052447A

  公开（公告）日：1977-10-04
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  申请人：——

  公开号：US9127019B2

  公开（公告）日：2015-09-08
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  申请人：——

  公开号：US9714255B2

  公开（公告）日：2017-07-25