6,6,6-Trifluorohexan-2-one | 1501305-11-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 6,6,6-Trifluorohexan-2-one
• CAS: 1501305-11-8
• 化学式: C₆H₉F₃O
• 分子量: 154.13
• InChiKey: JEFZBEYZGIMZKV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  10
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• [EN] PEPTIDOMIMETIC PROTEASOME INHIBITORS<br/>[FR] INHIBITEURS PEPTIDOMIMÉTIQUES DU PROTÉASOME
  申请人：UNIV CORNELL

  公开号：WO2019075252A1

  公开（公告）日：2019-04-18

  The compounds of the present invention are represented by the following compounds having Formula (I) and Formula (I'): where the substituents R, R1, R3 R4, R', W, X, Y, Z, k, and m are as defined herein and where the substituents R, R1, R2, R3, R4, X, Y, Z, and m are as defined herein. These compounds are used in the treatment of bacterial infections, parasite infections, fungal infections, cancer, immunologic disorders, autoimmune disorders, neurodegenerative diseases and disorders, inflammatory disorders, or muscular dystrophy or for providing immunosuppression for transplanted organs or tissues.

  本发明的化合物由具有式（I）和式（I'）的以下化合物表示：其中取代基R、R1、R3、R4、R'、W、X、Y、Z、k和m如本文所定义，取代基R、R1、R2、R3、R4、X、Y、Z和m如本文所定义。这些化合物用于治疗细菌感染、寄生虫感染、真菌感染、癌症、免疫紊乱、自身免疫性疾病、神经退行性疾病和紊乱、炎症性疾病，或肌肉萎缩症，或用于为移植的器官或组织提供免疫抑制。
• ISOTHIAZOLINE DERIVATIVES AS INSECTICIDAL COMPOUNDS
  申请人：Cassayre Jerome Yves

  公开号：US20140378415A1

  公开（公告）日：2014-12-25

  The present invention provides compounds of formula (I) wherein P is P0, heterocyclyl or heterocyclyl substituted by one to five Z formula (II); Y 1 , Y 2 , Y 3 and Y 4 are independently of each other C—H, C—R 5 , or nitrogen; G1 is oxygen or sulfur; X 4 is C 1 -C 8 haloalkyl; R 4 is aryl or aryl substituted by one to five R 9 , or heteroaryl or heteroaryl substituted by one to five R 9 ; and R 1 , R 2 , R 4 , R 5 , R 9 and Z are as defined in the claims. The invention also provides compositions comprising the compounds of formula (I), intermediates useful in the preparation of compounds of formula (I) and methods of using the compounds of formula (I) to control insects, acarines, nematodes or molluscs.

  本发明提供了公式（I）的化合物，其中P是P0、杂环基或杂环基上取代了1-5个Z式（II）；Y1、Y2、Y3和Y4独立地是C-H、C-R5或氮；G1是氧或硫；X4是C1-C8卤代烷基；R4是芳基或取代了1-5个R9的芳基，或杂芳基或取代了1-5个R9的杂芳基；而R1、R2、R4、R5、R9和Z的定义见权利要求。本发明还提供了包含公式（I）化合物的组合物、制备公式（I）化合物的中间体以及使用公式（I）化合物控制昆虫、螨、线虫或软体动物的方法。
• ISOXAZOLINES AS INHIBITORS OF FATTY ACID AMIDE HYDROLASE
  申请人：INFINITY PHARMACEUTICALS, INC.

  公开号：US20150099738A1

  公开（公告）日：2015-04-09

  The present invention provides isoxazoline FAAH inhibitors of the formula (I): or pharmaceutically acceptable forms thereof, wherein each of G, R a , R b , R c , and R d are as defined herein. The present invention also provides pharmaceutical compositions comprising a compound of formula (I), or a pharmaceutically acceptable form thereof, and a pharmaceutically acceptable excipient. The present invention also provides methods for treating an FAAH-mediated condition comprising administering a therapeutically effective amount of a compound of formula (I), or pharmaceutically acceptable form thereof, to a subject in need thereof.

  本发明提供了式（I）的异噁唑烷FAAH抑制剂或其药学上可接受的形式，其中G、Ra、Rb、Rc和Rd的定义如本文所述。本发明还提供了含有式（I）化合物或其药学上可接受的形式和药学上可接受的载体的制剂。本发明还提供了治疗FAAH介导疾病的方法，包括向需要治疗的受体中投与式（I）化合物或其药学上可接受的形式的治疗有效量。
• DIHYDROTHIOPHENE DERIVATIVES AS INSECTICIDAL COMPOUNDS
  申请人：SYNGENTA PARTICIPATIONS AG

  公开号：US20150272120A1

  公开（公告）日：2015-10-01

  The present invention provides compounds of formula (I) wherein Q is Q1 or Q2 P is P0, heterocyclyl or heterocyclyl substituted by one to five Z; Y 1 , Y 2 , Y 3 and Y 4 are independently of each other C—H, C—R 5 , or nitrogen; G 1 is oxygen or sulfur; R 1 is hydrogen, C 1 -C 8 alkyl, C 1 -C 8 alkoxy-, C 1 -C 8 alkylcarbonyl-, or C 1 -C 8 alkoxycarbonyl-; X 4 is C 1 -C 8 haloalkyl; R 4 is aryl or aryl substituted by one to five R 9 , or heteroaryl or heteroaryl substituted by one to five R 9 ; n is 0, 1 or 2; and Z, R 2 , R 5 and R 9 are as defined in the claims. The invention also provides methods of controlling insects, acarines, nematodes or molluscs comprising applying to a pest, to a locus of a pest, or to a plant susceptible to attack by a pest an insecticidally, acaricidally, nematicidally or molluscicidally effective amount of a compound of formula (I).

  本发明提供了式（I）的化合物，其中Q是Q1或Q2，P是P0，杂环基或杂环基上取代1至5个Z；Y1、Y2、Y3和Y4分别独立地是C-H、C-R5或氮；G1是氧或硫；R1是氢、C1-C8烷基、C1-C8烷氧基、C1-C8烷基羰基或C1-C8烷氧羰基；X4是C1-C8卤代烷基；R4是芳基或芳基上取代1至5个R9，或杂芳基或杂芳基上取代1至5个R9；n为0、1或2；以及Z、R2、R5和R9如权利要求所定义。本发明还提供了一种控制昆虫、螨、线虫或软体动物的方法，包括向害虫、害虫的地点或易受害虫攻击的植物施用式（I）的杀虫、杀螨、杀线虫或杀软体动物有效量的化合物。
• [EN] PYRAZOLOPYRIDINE COMPOUND AS RET INHIBITOR AND APPLICATION THEREOF<br/>[FR] COMPOSÉ DE PYRAZOLOPYRIDINE UTILISÉ COMME INHIBITEUR DE RET ET SON APPLICATION<br/>[ZH] 作为RET抑制剂的吡唑并吡啶类化合物及其应用
  申请人：MEDSHINE DISCOVERY INC

  公开号：WO2020200316A1

  公开（公告）日：2020-10-08

  本发明公开了一系列吡唑并吡啶类化合物，及其在制备治疗作为RET激酶抑制剂中的应用。具体公开了式（I）所示化合物或其药学上可接受的盐。