3-acetyl-4-hydroxy-1-(5-methoxypyrimidin-2-yl)-6-methylpyridin-2(1H)-one | 1312938-97-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-acetyl-4-hydroxy-1-(5-methoxypyrimidin-2-yl)-6-methylpyridin-2(1H)-one
• 英文别名: 3-Acetyl-4-hydroxy-1-(5-methoxypyrimidin-2-yl)-6-methylpyridin-2-one
• CAS: 1312938-97-8
• 化学式: C₁₃H₁₃N₃O₄
• 分子量: 275.264
• InChiKey: QZQCEMKHZFPMIP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  92.6
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• NOVEL 2-PYRIDONE DERIVATIVE AND PHARMACEUTICAL PRODUCT CONTAINING SAME
  申请人：Miura Toru

  公开号：US20120225896A1

  公开（公告）日：2012-09-06

  Disclosed is a novel 2-pyridone derivative represented by general formula (1), which has both angiotensin II receptor antagonist activity and PPAR-γ activating activity and is useful as a prophylactic and/or therapeutic agent for cardiovascular diseases and metabolic diseases. Also disclosed is a pharmaceutical composition which contains the novel 2-pyridone derivative. In general formula (1), R 1 represents a C 1-6 alkyl group or a C 1-6 alkoxy group; R 2 represents a C 1-6 alkyl group or a C 3-8 cycloalkyl group; R 3 represents a C 1-6 alkyl group, a C 6-10 aryl-C 1-6 alkyl group, a C 1-6 alkoxy-C 1-6 alkyl group or a group represented by formula (2) (wherein A represents a nitrogen atom or CH, and R 5 represents a hydrogen atom or a C 1-6 alkoxy group); and R 4 represents a group represented by formula (3) or (4).

  揭示了一种由通式（1）表示的新型2-吡啶酮衍生物，该衍生物具有抗血管紧张素II受体拮抗活性和PPAR-γ激活活性，并且可用作心血管疾病和代谢性疾病的预防和/或治疗剂。还揭示了一种含有该新型2-吡啶酮衍生物的药物组合物。在通式（1）中，R1代表C1-6烷基或C1-6烷氧基；R2代表C1-6烷基或C3-8环烷基；R3代表C1-6烷基、C6-10芳基-C1-6烷基、C1-6烷氧基-C1-6烷基或由通式（2）表示的基团（其中A代表氮原子或CH，R5代表氢原子或C1-6烷氧基）；R4代表由通式（3）或（4）表示的基团。