N-(5-chloro-pyridin-2-yl)-2-[4-(7-methoxy-quinolin-4-yloxy)-phenyl]-acetamide | 847604-82-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: N-(5-chloro-pyridin-2-yl)-2-[4-(7-methoxy-quinolin-4-yloxy)-phenyl]-acetamide
• 英文别名: N-(5-chloropyridin-2-yl)-2-[4-(7-methoxyquinolin-4-yl)oxyphenyl]acetamide
• CAS: 847604-82-4
• 化学式: C₂₃H₁₈ClN₃O₃
• 分子量: 419.867
• InChiKey: OQIHDWYSNNBZBT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  30
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  73.3
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• QUINOLINE DERIVATIVES
  申请人：Jung Frederic Henri

  公开号：US20090076075A1

  公开（公告）日：2009-03-19

  The invention concerns quinoline derivatives of Formula I or a pharmaceutically-acceptable salt thereof, wherein each of X 1 , p, R 1 , q, R 2 , R 3 , R 4 , R 5 Ring A, r and R 6 has any of the meanings defined hereinbefore in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use in the treatment of cell proliferative disorders.

  这项发明涉及公式I的喹啉衍生物或其药用盐，其中X 1 ，p，R 1 ，q，R 2 ，R 3 ，R 4 ，R 5 ，环A，r和R 6 中的每一个具有在描述中定义的任何含义；它们的制备方法，含有它们的药物组合物以及它们在制造用于治疗细胞增殖紊乱的药物的药物中的使用。
• QUINAZOLINE DERIVATIVES
  申请人：Jung Frederic Henri

  公开号：US20090233950A1

  公开（公告）日：2009-09-17

  The invention concerns quinazoline derivatives of Formula I or a pharmaceutically-acceptable salt thereof, wherein each of X 1 , p, R 1 , q, R 2 , R 3 , R 4 , R 5 , Ring A, r and R 6 has any of the meanings defined hereinbefore in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use in the treatment of cell proliferative disorders.

  该发明涉及公式I的喹唑啉衍生物或其药学上可接受的盐，其中X1、p、R1、q、R2、R3、R4、R5、环A、r和R6中的每一个都具有在说明中定义的任何含义；它们的制备方法，包含它们的制药组合物以及它们用于制造用于治疗细胞增殖性疾病的药物的用途。
• QUINOLINE DERIVATIVES FOR TREATING CANCER
  申请人：Jung Frederic Henri

  公开号：US20090042910A1

  公开（公告）日：2009-02-12

  The invention concerns quinoline derivatives of Formula I or a pharmaceutically-acceptable salt thereof, wherein each of X 1 , p, R 1 , q, R 2 , R 3 , R 4 , R 5 , Ring A, r and R 6 has any of the meanings defined hereinbefore in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use in the treatment of cell proliferative disorders.

  本发明涉及公式I的喹啉衍生物或其药学上可接受的盐，其中X1、p、R1、q、R2、R3、R4、R5、环A、r和R6中的每一个具有在本描述中定义的任何含义；制备它们的过程，含有它们的制药组合物以及它们在制造用于治疗细胞增殖性疾病的药物的过程中的使用。
• THIENOPYRIDINE-PHENYLACET AMIDES AND THEIR DERIVATIVES USEFUL AS NEW ANTI-ANGIOGENIC AGENTS
  申请人：PFIZER INC.

  公开号：EP1660504B1

  公开（公告）日：2008-10-29
• US7208500B2
  申请人：——

  公开号：US7208500B2

  公开（公告）日：2007-04-24