2-deoxy-3,4,6-tri-O-benzyl-α-D-lyxo-hexopyranosyl-(1->6)-3-hyroxy-1,2,4-tri-O-methyl-α-D-glucopyranose | 1327260-14-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-deoxy-3,4,6-tri-O-benzyl-α-D-lyxo-hexopyranosyl-(1->6)-3-hyroxy-1,2,4-tri-O-methyl-α-D-glucopyranose
• CAS: 1327260-14-9
• 化学式: C₃₀H₄₂O₁₀
• 分子量: 562.657
• InChiKey: RGAXZSMUNGYSBR-JXSRKGGGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  40.0
• 可旋转键数：
  14.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  103.3
• 氢给体数：
  1.0
• 氢受体数：
  10.0

反应信息

• 作为反应物：
  描述：

  2-deoxy-3,4,6-tri-O-benzyl-α-D-lyxo-hexopyranosyl-(1->6)-3-hyroxy-1,2,4-tri-O-methyl-α-D-glucopyranose 、 3-O-Acetyl-4,6-di-O-benzyl-D-galactal 在 aluminum (III) chloride 作用下， 以 二氯甲烷 为溶剂， 反应 1.33h， 以54%的产率得到
  参考文献：
  名称：

  Stereoselective glycosylation of endo-glycals by microwave- and AlCl3-assisted catalysis

  摘要：

  alpha-2-Deoxyglycosides were synthesized in good to excellent yields by microwave-assisted reaction of endo-glycals with various O-nucleophiles in the presence of catalytic amount of AlCl3. These glycosyl additions occurred with high alpha-stereoselectivity and were complete in 5-35 min in 65-93% yield. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2011.05.124
• 作为产物：
  描述：

  2-deoxy-3,4,6-tri-O-benzyl-α-D-lyxo-hexopyranosyl-(1->6)-3-acetyl-1,2,4-tri-O-methyl-α-D-glucopyranose 在 甲醇 、 potassium carbonate 作用下， 反应 4.0h， 以95%的产率得到2-deoxy-3,4,6-tri-O-benzyl-α-D-lyxo-hexopyranosyl-(1->6)-3-hyroxy-1,2,4-tri-O-methyl-α-D-glucopyranose
  参考文献：
  名称：

  Stereoselective glycosylation of endo-glycals by microwave- and AlCl3-assisted catalysis

  摘要：

  alpha-2-Deoxyglycosides were synthesized in good to excellent yields by microwave-assisted reaction of endo-glycals with various O-nucleophiles in the presence of catalytic amount of AlCl3. These glycosyl additions occurred with high alpha-stereoselectivity and were complete in 5-35 min in 65-93% yield. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2011.05.124