(2-(2,2-difluoroethoxy)pyridin-4-yl)methanamine | 1432680-35-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (2-(2,2-difluoroethoxy)pyridin-4-yl)methanamine
• 英文别名: [2-(2,2-Difluoroethoxy)pyridin-4-yl]methanamine
• CAS: 1432680-35-7
• 化学式: C₈H₁₀F₂N₂O
• mdl: MFCD23701780
• 分子量: 188.177
• InChiKey: HBVFKNAVLMBSQI-UHFFFAOYSA-N

物化性质

• 沸点：
  269.2±40.0 °C(Predicted)
• 密度：
  1.218±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.375
• 拓扑面积：
  48.1
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  N,N'-羰基二咪唑 、 2-[1-(三氟甲基)环丙基]乙-1-胺盐酸盐 、 (2-(2,2-difluoroethoxy)pyridin-4-yl)methanamine 在 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 为溶剂， 以87 %的产率得到1-((2-(2,2-difluoroethoxy)pyridin-4-yl)methyl)-3-(2-(1-(trifluoromethyl)cyclopropyl)ethyl)urea
  参考文献：
  名称：

  UREA COMPOUNDS AS ACTIVATORS OF POTASSIUM CHANNELS KV7.2/7.3 USEFUL IN THE TREATMENT OF CNS AND PNS DISORDERS

  摘要：

  The present invention relates to compounds of formula (I) as defined in the specification capable of promoting the opening of Kv7.2/7.3 potassium channels, a pharmaceutical composition comprising them, and their use as a drug, particularly in the treatment of disorders of the central nervous system (CNS), such as, for example, epilepsy and neurodegenerative disorders, and of the peripheral nervous system (PNS), such as, for example, chronic and neuropathic pain.

  公开号：

  WO2024121048A1

文献信息

• NOVEL HETEROARYL-UREA COMPOUNDS AS KV7.2 INHIBITORS
  申请人：[en]ICAGEN, LLC

  公开号：WO2023091554A1

  公开（公告）日：2023-05-25

  The invention provides new heteroaromatic compounds having the general formula (I'), or a solvate or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, Y1, Y2, Y3, and n are as defined herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.