2-methyl-4-(5-methyl-2-thienyl)-1,3-thiazole | 1450665-80-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-methyl-4-(5-methyl-2-thienyl)-1,3-thiazole
• 英文别名: 2-Methyl-4-(5-methylthiophen-2-yl)-1,3-thiazole
• CAS: 1450665-80-1
• 化学式: C₉H₉NS₂
• 分子量: 195.309
• InChiKey: MMWZOSBCEKPAKH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.222
• 拓扑面积：
  69.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-methyl-4-(5-methyl-2-thienyl)-1,3-thiazole 在 aluminum (III) chloride 、 potassium carbonate 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 18.0h， 生成 3-(2,5-dimethylthiophen-3-yl)-4-[2-methyl-5-(2-methylthiazol-4-yl)thiophen-3-yl]furan-2,5-dione
  参考文献：
  名称：

  Synthesis and photochromic properties of dithienylmaleimides with sulfur-containing fragments

  摘要：

  合成了多种含硫二噻吩马来酰亚胺衍生物。对所得化合物的光谱和动力学特性进行了研究，结果表明合成的所有二噻吩乙烯均具有光致变色性能。

  DOI：

  10.1007/s11172-012-0295-z
• 作为产物：
  描述：

  2-甲基噻吩 在 aluminum (III) chloride 作用下， 以 乙醇 为溶剂， 反应 2.0h， 生成 2-methyl-4-(5-methyl-2-thienyl)-1,3-thiazole
  参考文献：
  名称：

  Synthesis and photochromic properties of dithienylmaleimides with sulfur-containing fragments

  摘要：

  合成了多种含硫二噻吩马来酰亚胺衍生物。对所得化合物的光谱和动力学特性进行了研究，结果表明合成的所有二噻吩乙烯均具有光致变色性能。

  DOI：

  10.1007/s11172-012-0295-z

文献信息

• Linear urea mimics antagonists of P2Y1 receptor useful in the treatment of thrombotic condition
  申请人：Chao J. Hannguang

  公开号：US20070004677A1

  公开（公告）日：2007-01-04

  The present invention provides novel urea mimics and analogues of Formula (I): or a stereoisomer, tautomer, pharmaceutically acceptable salt or solvate form thereof, wherein the variables A, B, W, and R 6 are as defined herein. These compounds are selective inhibitors of the human P2Y 1 receptor which can be used as medicaments.

  本发明提供了新颖的尿素类似物和类似物，其化学式为（I）：或其立体异构体、互变异构体、药学上可接受的盐或溶剂形式，其中变量A、B、W和R6如本文所定义。这些化合物是人类P2Y1受体的选择性抑制剂，可用作药物。
• N,N-SUBSTITUTED 3-AMINOPYRROLIDINE COMPOUNDS USEFUL AS MONOAMINES REUPTAKE INHIBITORS
  申请人：Kurimura Muneaki

  公开号：US20090088406A1

  公开（公告）日：2009-04-02

  The present invention provides a pyrrolidine compound of General Formula (1) or a salt thereof, wherein R 101 and R 102 are each independently a phenyl group or a pyridyl group, the phenyl group or the pyridyl group may have one or more substituents selected from halogen atoms and lower alkyl groups optionally substituted with one or more halogen atoms, etc. The pyrrolidine compound or a salt thereof of the present invention is usable to produce a pharmaceutical preparation having a wider therapeutic spectrum and being capable of exhibiting sufficient therapeutic effects after short-term administration.

  本发明提供了一种吡咯烷化合物，其一般式为（1），或其盐，其中R101和R102分别是苯基或吡啶基，苯基或吡啶基可以具有一个或多个卤原子和低碳基团，可选地取代一个或多个卤原子等。本发明的吡咯烷化合物或其盐可用于制备具有更广泛治疗谱并能够在短期内展现足够治疗效果的药物制剂。
• Imine Compound
  申请人：Saito Shiuji

  公开号：US20080312435A1

  公开（公告）日：2008-12-18

  An imine compound represented by the formula: wherein A represents a heterocyclic group; R 1 , R 2 , an R 3 each represent a hydrogen atom, a halogen atom, a C 1-10 alkyl group optionally substituted with an aryl group(s) substituted with a halogen atom(s), a C 3-10 cycloalkyl group, a C 1-6 haloalkyl group, a C 1-10 alkoxy group, etc.; R 4 represents an optionally substituted C 1-10 alkyl, C 2-6 alkenyl, or aryl group; R 5 represents a hydrogen atom, a C 1-10 alkoxy group, a C 1-6 haloalkyl group, an optionally substituted C 1-10 alkyl or C 2-6 alkenyl group, an optionally substituted aryl or heterocyclic group, etc.; W represents —CO—, —CO—CO—, —CO—NH—, —CS—NH—, or —SO 2 —, or a cannabinoid-receptor agonist comprising said imine compound as an active ingredient. The imine compound of the present invention has a cannabinoid-receptor agonist effect, and is useful as a therapeutic or prophylactic drug for pains and autoimmune diseases.

  一种以以下式表示的亚胺化合物：其中A代表杂环基团；R1、R2和R3分别表示氢原子、卤素原子、C1-10烷基，该烷基可选地取代有芳基，所述芳基取代有卤素原子，C3-10环烷基，C1-6卤代烷基，C1-10烷氧基等；R4表示可选地取代的C1-10烷基，C2-6烯基或芳基；R5表示氢原子，C1-10烷氧基，C1-6卤代烷基，可选地取代的C1-10烷基或C2-6烯基，可选地取代的芳基或杂环基团等；W表示—CO—，—CO—CO—，—CO—NH—，—CS—NH—或—SO2—，或以该亚胺化合物为活性成分的大麻素受体激动剂。本发明的亚胺化合物具有大麻素受体激动剂作用，可用作治疗或预防疼痛和自身免疫性疾病的药物。
• N-N-SUBSTITUTED 3-AMINOPYRROLIDINE COMPOUNDS USEFUL AS MONOAMINES REUPTAKE INHIBITORS
  申请人：KURIMURA Muneaki

  公开号：US20120065162A1

  公开（公告）日：2012-03-15

  The present invention provides a pyrrolidine compound of General Formula (1) or a salt thereof, wherein R 101 and R 102 are each independently a phenyl group or a pyridyl group, the phenyl group or the pyridyl group may have one or more substituents selected from halogen atoms and lower alkyl groups optionally substituted with one or more halogen atoms, etc. The pyrrolidine compound or a salt thereof of the present invention is usable to produce a pharmaceutical preparation having a wider therapeutic spectrum and being capable of exhibiting sufficient therapeutic effects after short-term administration.

  本发明提供了一种吡咯烷化合物通式（1）或其盐，其中R101和R102各自独立地为苯基或吡啶基，所述苯基或吡啶基可以具有一个或多个卤素原子和低碳基团中的一个或多个卤素原子等取代基。本发明的吡咯烷化合物或其盐可用于制备具有更广泛治疗谱并能够在短期内展现足够治疗效果的药物制剂。
• N,N-substituted 3-aminopyrrolidine compounds useful as monoamines reuptake inhibitors
  申请人：OTSUKA PHARMACEUTICAL CO., LTD.

  公开号：US10000450B2

  公开（公告）日：2018-06-19

  The present invention provides a pyrrolidine compound of General Formula (1) or a salt thereof, wherein R101 and R102 are each independently a phenyl group or a pyridyl group, the phenyl group or the pyridyl group may have one or more substituents selected from halogen atoms and lower alkyl groups optionally substituted with one or more halogen atoms, etc. The pyrrolidine compound or a salt thereof of the present invention is usable to produce a pharmaceutical preparation having a wider therapeutic spectrum and being capable of exhibiting sufficient therapeutic effects after short-term administration.

  本发明提供了通式（1）的吡咯烷化合物 或其盐，其中 R101 和 R102 各自独立地为苯基或吡啶基，苯基或吡啶基可具有一个或多个选自卤素原子和任选被一个或多个卤素原子取代的低级烷基等的取代基。本发明的吡咯烷化合物或其盐可用于生产具有更广治疗范围的药物制剂，并能在短期给药后显示出足够的治疗效果。