4-(bis(2-(tetradecanoyloxy)ethyl)amino)-4-oxobutanoic acid | 1402925-52-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 4-(bis(2-(tetradecanoyloxy)ethyl)amino)-4-oxobutanoic acid
• 英文别名: 4-[Bis(2-tetradecanoyloxyethyl)amino]-4-oxobutanoic acid
• CAS: 1402925-52-3
• 化学式: C₃₆H₆₇NO₇
• 分子量: 625.93
• InChiKey: DEAVAFKEVFXFAA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  11.4
• 重原子数：
  44
• 可旋转键数：
  35
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  110
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  Benzyl 4-[bis(2-hydroxyethyl)amino]-4-oxobutanoate 、 4-(bis(2-(tetradecanoyloxy)ethyl)amino)-4-oxobutanoic acid 在 4-二甲氨基吡啶 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 反应 24.0h， 以70%的产率得到
  参考文献：
  名称：

  Design and Synthesis of Novel Janus Dendrimers as Lipophilized Antioxidants

  摘要：

  In the search for better antioxidants with more satisfactory lipophilicity, a series of Janus dendrimers that consisted of gallic acid and alkyl chains as the peripheral groups, were designed and synthesized. These dendrimers take advantage of a dendritic display to carry multi-antioxidants and multi-lipophilic moieties simultaneously. Consequently, the resulting dendrimers, which showed satisfactory lipophilicity and better antioxidant activity than the gallic acid monomer, are potential novel lipophilized antioxidant agents.

  DOI：

  10.1055/s-0032-1318457
• 作为产物：
  描述：

  2-[Phenylmethoxycarbonyl(2-tetradecanoyloxyethyl)amino]ethyl tetradecanoate 在 氢气 、 N,N-二异丙基乙胺 作用下， 以 四氢呋喃 、 甲醇 、 乙酸乙酯 为溶剂， 20.0 ℃ 、101.33 kPa 条件下， 反应 20.5h， 生成 4-(bis(2-(tetradecanoyloxy)ethyl)amino)-4-oxobutanoic acid
  参考文献：
  名称：

  PEGYLATED LIPID COMPOUNDS AND METHODS OF USE THEREOF

  摘要：

  The present disclosure relates to PEGylated lipid compounds and pharmaceutically acceptable salts thereof. Such compounds are useful, for example, as constituent parts of lipid nanoparticle (LNP) formulations for delivery of various active agents. The present disclosure further provides LNPs comprising a disclosed compound. Also provided herein are methods of preparing such PEGylated lipid compounds, as well as pharmaceutical compositions comprising an LNP and an active agent; and methods of use thereof.

  公开号：

  WO2024044728A1

文献信息

• Synthesis, Antibacterial Activity and Cytotoxicity of Novel Janus Peptide Dendrimers
  作者：Li Guo、Junzhu Pan、Liang Ouyang、Dongqin Yin、Yi Zhao

  DOI：10.1055/s-0031-1290403

  日期：2012.8

  In an attempt to find new antibacterial agents, a series of well-defined Janus peptide dendrimers, which feature multiple anionic groups and amphiphilic structure, were synthesized and characterized in detail. The antibacterial activities of all the synthesized dendrimers were tested and screened by using the two-fold serial dilution method. Several compounds showed activity against E. coli, S. aureus, methicillin-resistant S. aureus, and E. faecalis. Further cytotoxicity assays showed that the antibacterial dendrimers were nontoxic against HEK293.
• FUSOGENIC COMPOUNDS FOR DELIVERY OF BIOLOGICALLY ACTIVE MOLECULES
  申请人：Nitto Denko Corporation

  公开号：US20190133948A1

  公开（公告）日：2019-05-09

  This invention includes fusogenic compounds, and compositions and methods of use thereof. The fusogenic compounds can be used for making nanoparticle compositions for use in biopharmaceuticals and therapeutics. More particularly, this invention relates to compounds, compositions and methods for providing nanoparticles to incorporate or encapsulate active agents, to deliver and distribute the active agents to cells, tissues, organs, and subjects.