((2S,3S,5R)-3-amino-5-(6-(benzylamino)-9H-purin-9-yl)tetrahydrofuran-2-yl)methanol | 1061382-87-3

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷
• 英文名称: ((2S,3S,5R)-3-amino-5-(6-(benzylamino)-9H-purin-9-yl)tetrahydrofuran-2-yl)methanol
• CAS: 1061382-87-3
• 化学式: C₁₇H₂₀N₆O₂
• 分子量: 340.385
• InChiKey: FHMWVWVSBRGOJA-BFHYXJOUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.05
• 重原子数：
  25.0
• 可旋转键数：
  5.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  111.11
• 氢给体数：
  3.0
• 氢受体数：
  8.0

反应信息

• 作为产物：
  描述：

  6-苄氨基嘌呤 、 3'-氨基-2',3'-双脱氧鸟苷 在 purine nucleoside phosphorylase 、 potassium phosphate buffer 作用下， 生成 ((2S,3S,5R)-3-amino-5-(6-(benzylamino)-9H-purin-9-yl)tetrahydrofuran-2-yl)methanol
  参考文献：
  名称：

  An Enzymatic Transglycosylation of Purine Bases

  摘要：

  An enzymatic transglycosylation of purine heterocyclic bases employing readily available natural nucleosides or sugar-modified nucleosides as donors of the pentofuranose fragment and recombinant nucleoside phosphorylases as biocatalysts has been investigated. An efficient enzymatic method is suggested for the synthesis of purine nucleosides containing diverse substituents at the C6 and C2 carbon atoms. The glycosylation of N-6-benzoyladenine and N-2-acetylguanine and its O-6-derivatives is not accompanied by deacylation of bases.

  DOI：

  10.1080/15257770701506343