4-氨基-3-(2,2-二甲氧基乙基)-苯酚 | 250739-30-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 4-氨基-3-(2,2-二甲氧基乙基)-苯酚
• 英文名称: 4-Amino-3-(2,2-dimethoxyethyl)phenol
• CAS: 250739-30-1
• 化学式: C₁₀H₁₅NO₃
• mdl: MFCD03093391
• 分子量: 197.234
• InChiKey: ZKIYQLYEPCQCBB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  64.7
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-氨基-3-(2,2-二甲氧基乙基)-苯酚 在 吡啶 、 2,3,5-三甲基吡啶 、 四氧化锇 、 N-甲基吲哚酮 、 碘苯二乙酸 作用下， 以 四氢呋喃 、 二氯甲烷 、 水 为溶剂， 反应 4.0h， 生成 [12,13-Dihydroxy-4-(4-methylphenyl)sulfonyl-4-azatetracyclo[9.2.1.02,10.03,7]tetradeca-2,5,7,9-tetraen-9-yl] trifluoromethanesulfonate
  参考文献：
  名称：

  Total Synthesis of (±)-Herbindole B and (±)-cis-Trikentrin B

  摘要：

  Herbindole B and cis-trikentrin B are naturally occurring indoles having the unusual and synthetically challenging pattern of carbon substitution at the 4-7 and 5-7 positions, respectively, with no substitution at the 1-3 positions. The total syntheses of these polyalkylated indoles have been achieved in 19 and 12 steps, respectively. The synthesis of herbindole B relies on two iterations of a quinine monoimine Diels-Alder reaction, while cis-trikentrin B uses a single cycloaddition of a suitable quinone monolmine. Indolization of the adducts provides suitably substituted benzopyrrole nuclei for elaboration to the natural products.

  DOI：

  10.1021/ol047498k
• 作为产物：
  描述：

  4-硝基间甲苯酚 在 palladium on activated charcoal camphor-10-sulfonic acid 、 氢气 、 caesium carbonate 作用下， 以 乙醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 88.0h， 生成 4-氨基-3-(2,2-二甲氧基乙基)-苯酚
  参考文献：
  名称：

  A Novel Safety-Catch Linker for the Solid-Phase Synthesis of Amides and Esters

  摘要：

  [GRAPHICS]A new safety catch linker for solid phase organic synthesis is described. Synthesis and attachment of the linker to the solid phase was achieved via a simple and high yielding strategy. The linker was exemplified by acylation to form unactivated amides, activation of the linker, and cleavage to release acyl moieties. Acids, amides, or esters were released under mild conditions and with exceptionally high purity. The reactivities of unactivated and activated amides are compared.

  DOI：

  10.1021/ol990785h

文献信息

• BIFUNCTIONAL MOLECULES FOR INHIBITING HIV ENTRY
  申请人：New York Blood Center

  公开号：EP2291392A1

  公开（公告）日：2011-03-09
• Bifunctional Molecules for Inhibiting HIV Entry
  申请人：Jiang Shibo

  公开号：US20090298774A1

  公开（公告）日：2009-12-03

  Disclosed herein are bifunctional molecules which inhibit HIV entry into the target cell. Also disclosed are novel anti-HIV therapeutics for treatment of patients infected by HIV, including non-B and multi-drug resistant strains.
• US8828931B2
  申请人：——

  公开号：US8828931B2

  公开（公告）日：2014-09-09
• [EN] BIFUNCTIONAL MOLECULES FOR INHIBITING HIV ENTRY<br/>[FR] MOLÉCULES BIFONCTIONNELLES DESTINÉES À INHIBER LA PÉNÉTRATION DU VIH
  申请人：NEW YORK BLOOD CT INC

  公开号：WO2009155064A1

  公开（公告）日：2009-12-23

  Disclosed herein are bifunctional molecules which inhibit HIV entry into the target cell. Also disclosed are novel anti-HIV therapeutics for treatment of patients infected by HIV, including non-B and multi-drug resistant strains.
• A Novel Safety-Catch Linker for the Solid-Phase Synthesis of Amides and Esters
  作者：Matthew H. Todd、Steven F. Oliver、Chris Abell

  DOI：10.1021/ol990785h

  日期：1999.10.1

  [GRAPHICS]A new safety catch linker for solid phase organic synthesis is described. Synthesis and attachment of the linker to the solid phase was achieved via a simple and high yielding strategy. The linker was exemplified by acylation to form unactivated amides, activation of the linker, and cleavage to release acyl moieties. Acids, amides, or esters were released under mild conditions and with exceptionally high purity. The reactivities of unactivated and activated amides are compared.