(4R)-3,5,5-trichloro-4-hydroxycyclopent-2-enone | 71268-67-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (4R)-3,5,5-trichloro-4-hydroxycyclopent-2-enone
• 英文别名: (4R)-3,5,5-Trichlorcyclopent-2-enon；(4R)-3,5,5-Trichloro-4-hydroxycyclopent-2-en-1-one
• CAS: 71268-67-2
• 化学式: C₅H₃Cl₃O₂
• 分子量: 201.437
• InChiKey: CORISGHUUZQHJD-SCSAIBSYSA-N

物化性质

• 沸点：
  305.3±42.0 °C(Predicted)
• 密度：
  1.72±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (4R)-3,5,5-trichloro-4-hydroxycyclopent-2-enone 、 无水氯化铬(Ⅱ) 生成 (4S)-3-Chloro-4-hydroxycyclopent-2-en-1-one
  参考文献：
  名称：

  RICKARDS, R. W.;GILL, M.;CHRISTIE, R. M.

  摘要：

  DOI：
• 作为产物：
  描述：

  (1RS,4RS)-3,5,5-trichloro-1,4-dihydroxycyclopent-2-ene-1-carboxylic acid 、 lead(IV) acetate 生成 (4R)-3,5,5-trichloro-4-hydroxycyclopent-2-enone
  参考文献：
  名称：

  RICKARDS, R. W.;GILL, M.;CHRISTIE, R. M.

  摘要：

  DOI：

文献信息

• Process for the preparation of prostanoids
  申请人：The Australian National University

  公开号：US04703127A1

  公开（公告）日：1987-10-27

  Compounds of the general formula I are disclosed as useful intermediates in the preparation of prostanoids: ##STR1## wherein A represents O or H, OR.sup.z ; R.sup.z represents hydrogen or a protecting group; R.sup.x represents hydrogen or a protecting group; and R.sup.y represents halogen, a substituted thio group, di-substituted amino group, or a group of the formula R.sup.2, and R.sup.2 represents a straight- or branched-chain alkyl alkenyl or alkynyl group which may optionally be substituted by one or more carboxyl, carboxylic acid ester, or free or protected hydroxyl, thiol, aldehyde or keto groups; with the provisos that R.sup.x is not hydrogen when A is O and R.sup.y is R.sup.2 ; and that when A is H, OR.sup.z R.sup.y and R.sup.2 and R.sup.x and R.sup.z are not both hydrogen. Processes for the preparation of these compounds and of 2-substituted 4-hydroxy-cyclopent-2-en-1-one derivatives are also disclosed.

  公式I的化合物被披露为制备前列腺素中间体的有用化合物：其中A代表O或H，OR.sup.z; R.sup.z代表氢或保护基; R.sup.x代表氢或保护基; R.sup.y代表卤素，取代的硫代基，二取代氨基基团，或者式子R.sup.2的基团，其中R.sup.2代表一种直链或支链烷基烯基或炔基，可以选择地被一个或多个羧酸，羧酸酯，或自由或保护的羟基，硫醇，醛或酮基团取代; 前提是当A为O且R.sup.y为R.sup.2时，R.sup.x不是氢，当A为H时，OR.sup.z R.sup.y和R.sup.2和R.sup.x和R.sup.z不都是氢。还披露了制备这些化合物和2-取代的4-羟基环戊-2-烯-1-酮衍生物的方法。
• 4-Oxy-cyclopent-2-en-1-one derivative, a prostaglandin intermediate, and
  申请人：The Australian National University

  公开号：US04367340A1

  公开（公告）日：1983-01-04

  Compounds of the general formula I are disclosed as useful intermediates in the preparation of prostanoids: ##STR1## wherein A represents O or H, OR.sub.z ; R.sup.z represents hydrogen or a protecting group; R.sup.x represents hydrogen or a protecting group; and R.sup.y represents halogen, a substituted thio group, di-substituted amino group, or a group of the formula R.sup.2, and R.sup.2 represents a straight-or branched-chain alkyl alkenyl or alkynyl group which may optionally be substituted by one or more carboxyl, carboxylic acid ester, or free or protected hydroxyl, thiol, aldehyde or keto groups; with the provisos that R.sup.x is not hydrogen when A is O and R.sup.y is R.sup.2 ; and that when A is H, OR.sup.z R.sup.y is R.sup.2 and R.sup.x and R.sup.z are not both hydrogen. Processes for the preparation of these compounds and of 2-substituted 4-hydroxy-cyclopent-2-en-1-one derivatives are also disclosed.

  公式I的化合物被披露为制备前列腺素中间体的有用化合物：##STR1## 其中A代表O或H，OR.sub.z; R.sup.z代表氢或保护基；R.sup.x代表氢或保护基；R.sup.y代表卤素，取代硫基，二取代氨基基团或式R.sup.2的基团，R.sup.2代表一种直链或支链烷基，烯基或炔基，它可以选择性地被一个或多个羧酸，羧酸酯或自由或保护的羟基，硫醇，醛或酮基团取代；条件是当A为O且R.sup.y为R.sup.2时，R.sup.x不是氢；当A为H时，OR.sup.z R.sup.y为R.sup.2且R.sup.x和R.sup.z不都是氢。还披露了制备这些化合物和2-取代的4-羟基环戊-2-烯-1-酮衍生物的方法。
• Cyclopentenone and cyclopentenol derivatives and processes for their preparation
  申请人：THE AUSTRALIAN NATIONAL UNIVERSITY

  公开号：EP0009892A1

  公开（公告）日：1980-04-16

  Compounds of the general formula I are disclosed as useful intermediates in the preparation of prostanoids: wherein A represents 0 or H, ORz; Rz represents hydrogen or a protecting group; Rx represents hydrogen or a protecting group; and Ry represents halogen, a substituted thio group, di-substituted amino group, or a group of the formula R2, and R2 represents a straight-or branched-chain alkyl, alkenyl or alkynyl group which may optionally be substituted by one or more carboxyl, carboxylic acid ester, or free or protected hydroxyl, thiol, aldehyde or keto groups; with the provisos that Rx is not hydrogen when A is O and Ry is R2; and that when A is H, ORz RY is R2 and RX and Rz are not both hydrogen. Processes forthe preparation of these compounds and of 2-substituted 4-hydroxy-cyclopent-2-en-1-one derivatives are also disclosed.

  通式 I 的化合物是制备前列腺素的有用中间体： 其中 A 代表 0 或 H、ORz； Rz 代表氢或保护基团 Rx 代表氢或保护基团；以及 R2 代表直链或支链烷基、烯基或炔基，可任选被一个或多个羧基、羧酸酯或游离或保护羟基、硫醇、醛基或酮基取代；但条件是，当 A 为 O，Ry 为 R2 时，Rx 不是氢；当 A 为 H，ORz RY 为 R2 时，RX 和 Rz 都不是氢。 还公开了这些化合物和 2-取代的 4-羟基-环戊-2-烯-1-酮衍生物的制备方法。
• US4367340A
  申请人：——

  公开号：US4367340A

  公开（公告）日：1983-01-04
• US4703127A
  申请人：——

  公开号：US4703127A

  公开（公告）日：1987-10-27