(3-Amino-pyrazin-2-yl)-[(S)-2-(tert-butyl-diphenyl-silanyloxymethyl)-pyrrolidin-1-yl]-methanone | 209627-37-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: (3-Amino-pyrazin-2-yl)-[(S)-2-(tert-butyl-diphenyl-silanyloxymethyl)-pyrrolidin-1-yl]-methanone
• CAS: 209627-37-2
• 化学式: C₂₆H₃₂N₄O₂Si
• 分子量: 460.651
• InChiKey: ATFORYDYJFCTQV-FQEVSTJZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.24
• 重原子数：
  33.0
• 可旋转键数：
  6.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  81.34
• 氢给体数：
  1.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  (3-Amino-pyrazin-2-yl)-[(S)-2-(tert-butyl-diphenyl-silanyloxymethyl)-pyrrolidin-1-yl]-methanone 在 六氯乙烷 、 四丁基氟化铵 、 三乙胺 作用下， 以 四氢呋喃 、 苯 为溶剂， 反应 4.0h， 生成 N-[(2S)-2-(hydroxymethyl)pyrrolidine]-3-(triphenylphosphoranylidene)aminopyrazine-2-carboxamide
  参考文献：
  名称：

  Synthesis of pyrazino[2,3-e][1,4]diazepin-5-one and pyrazino[2,3-e]pyrrolo[1,2-a][1,4]diazepin-5-one derivatives via the intramolecular aza-Wittig reaction

  摘要：

  2-Alkoxy pyrazino[2,3-e][1,4]diazepin-5-one and 11-alkoxy pyrazino[2,3-e]pyrrolo[1,2-a][1,4ldiazepin-5-one derivatives were synthesized via the corresponding iminophosphoranes derived from 3-aminopyrazine-2-carboxylic acid and a-amino acid derivatives, by the intramolecular aza-Wittig methodology. (11S, 11aS)-1,2,3,10,11,11a-Hexahydro-11-alkoxy-pyrazino[2,3-e]pyrrolo[1,2-a][1,4]diazepin-5-one derivatives, i.e.. 6,9-diaza-analogs of porothramycin B etc., were obtained. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(98)00256-7
• 作为产物：
  描述：

  3-氨基吡嗪-2-羧酸 、 (S)-2-(((tert-butyldiphenylsilyl)oxy)methyl)pyrrolidine 在 氰基磷酸二乙酯 、 三乙胺 作用下， 以 乙二醇二甲醚 为溶剂， 以100%的产率得到(3-Amino-pyrazin-2-yl)-[(S)-2-(tert-butyl-diphenyl-silanyloxymethyl)-pyrrolidin-1-yl]-methanone
  参考文献：
  名称：

  Synthesis of pyrazino[2,3-e][1,4]diazepin-5-one and pyrazino[2,3-e]pyrrolo[1,2-a][1,4]diazepin-5-one derivatives via the intramolecular aza-Wittig reaction

  摘要：

  2-Alkoxy pyrazino[2,3-e][1,4]diazepin-5-one and 11-alkoxy pyrazino[2,3-e]pyrrolo[1,2-a][1,4ldiazepin-5-one derivatives were synthesized via the corresponding iminophosphoranes derived from 3-aminopyrazine-2-carboxylic acid and a-amino acid derivatives, by the intramolecular aza-Wittig methodology. (11S, 11aS)-1,2,3,10,11,11a-Hexahydro-11-alkoxy-pyrazino[2,3-e]pyrrolo[1,2-a][1,4]diazepin-5-one derivatives, i.e.. 6,9-diaza-analogs of porothramycin B etc., were obtained. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(98)00256-7

文献信息

• Synthesis of pyrazino[2,3-e][1,4]diazepin-5-one and pyrazino[2,3-e]pyrrolo[1,2-a][1,4]diazepin-5-one derivatives via the intramolecular aza-Wittig reaction
  作者：Tomohiro Okawa、Shoji Eguchi

  DOI：10.1016/s0040-4020(98)00256-7

  日期：1998.5

  2-Alkoxy pyrazino[2,3-e][1,4]diazepin-5-one and 11-alkoxy pyrazino[2,3-e]pyrrolo[1,2-a][1,4ldiazepin-5-one derivatives were synthesized via the corresponding iminophosphoranes derived from 3-aminopyrazine-2-carboxylic acid and a-amino acid derivatives, by the intramolecular aza-Wittig methodology. (11S, 11aS)-1,2,3,10,11,11a-Hexahydro-11-alkoxy-pyrazino[2,3-e]pyrrolo[1,2-a][1,4]diazepin-5-one derivatives, i.e.. 6,9-diaza-analogs of porothramycin B etc., were obtained. (C) 1998 Elsevier Science Ltd. All rights reserved.